doi:10.1038/s41562-020-0931-9engAleta, A.Martín-Corral, D.Pastore y Piontti, A.Ajelli, M.Litvinova, M.Chinazzi, M.Dean, N.E.Halloran, M.E.Longini Jr, I.M.Merler, S.Pentland, A.Vespignani, A.Moro, E.Moreno, Y.Modelling the impact of testing, contact tracing and household quarantine on second waves of COVID-19ART-2020-119821While severe social-distancing measures have proven effective in slowing the coronavirus disease 2019 (COVID-19) pandemic, second-wave scenarios are likely to emerge as restrictions are lifted. Here we integrate anonymized, geolocalized mobility data with census and demographic data to build a detailed agent-based model of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission in the Boston metropolitan area. We find that a period of strict social distancing followed by a robust level of testing, contact-tracing and household quarantine could keep the disease within the capacity of the healthcare system while enabling the reopening of economic activities. Our results show that a response system based on enhanced testing and contact tracing can have a major role in relaxing social-distancing interventions in the absence of herd immunity against SARS-CoV-2.2020http://zaguan.unizar.es/record/12755210.1038/s41562-020-0931-9http://zaguan.unizar.es/record/127552oai:zaguan.unizar.es:127552info:eu-repo/grantAgreement/ES/DGA/E36-17R-FENOLinfo:eu-repo/grantAgreement/ES/MINECO/FIS2016-78904-C3-3-Pinfo:eu-repo/grantAgreement/ES/MINECO/FIS2017-87519-PNature human behaviour 4 (2020), 964-971byhttps://creativecommons.org/licenses/by/4.0/deed.esinfo:eu-repo/semantics/openAccess