000127583 001__ 127583
000127583 005__ 20241125101155.0
000127583 0247_ $$2doi$$a10.1002/cnm.3760
000127583 0248_ $$2sideral$$a134609
000127583 037__ $$aART-2023-134609
000127583 041__ $$aeng
000127583 100__ $$aJuma, Victor Ogesa$$uUniversidad de Zaragoza
000127583 245__ $$aEffects of tumour heterogeneous properties on modelling the transport of radiative particles
000127583 260__ $$c2023
000127583 5060_ $$aAccess copy available to the general public$$fUnrestricted
000127583 5203_ $$aDose calculation plays a critical role in radiotherapy (RT) treatment planning, and there is a growing need to develop accurate dose deposition models that incorporate heterogeneous tumour properties. Deterministic models have demonstrated their capability in this regard, making them the focus of recent treatment planning studies as they serve as a basis for simplified models in RT treatment planning. In this study, we present a simplified deterministic model for photon transport based on the Boltzmann transport equation (BTE) as a proof‐of‐concept to illustrate the impact of heterogeneous tumour properties on RT treatment planning. We employ the finite element method (FEM) to simulate the photon flux and dose deposition in real cases of diffuse intrinsic pontine glioma (DIPG) and neuroblastoma (NB) tumours. Importantly, in light of the availability of pipelines capable of extracting tumour properties from magnetic resonance imaging (MRI) data, we highlight the significance of such data. Specifically, we utilise cellularity data extracted from DIPG and NB MRI images to demonstrate the importance of heterogeneity in dose calculation. Our model simplifies the process of simulating a RT treatment system and can serve as a useful starting point for further research. To simulate a full RT treatment system, one would need a comprehensive model that couples the transport of electrons and photons.
000127583 536__ $$9info:eu-repo/grantAgreement/EC/H2020/826494/EU/PRedictive In-silico Multiscale Analytics to support cancer personalized diaGnosis and prognosis, Empowered by imaging biomarkers/PRIMAGE$$9This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 826494-PRIMAGE$$9info:eu-repo/grantAgreement/ES/MCIU/FPU18/04541$$9info:eu-repo/grantAgreement/ES/MICINN/PLEC2021-007709/AEI/10.13039/501100011033
000127583 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
000127583 590__ $$a2.2$$b2023
000127583 592__ $$a0.573$$b2023
000127583 591__ $$aMATHEMATICS, INTERDISCIPLINARY APPLICATIONS$$b39 / 135 = 0.289$$c2023$$dQ2$$eT1
000127583 593__ $$aApplied Mathematics$$c2023$$dQ2
000127583 591__ $$aMATHEMATICAL & COMPUTATIONAL BIOLOGY$$b31 / 66 = 0.47$$c2023$$dQ2$$eT2
000127583 593__ $$aBiomedical Engineering$$c2023$$dQ2
000127583 591__ $$aENGINEERING, BIOMEDICAL$$b82 / 123 = 0.667$$c2023$$dQ3$$eT3
000127583 593__ $$aSoftware$$c2023$$dQ2
000127583 593__ $$aModeling and Simulation$$c2023$$dQ2
000127583 593__ $$aComputational Theory and Mathematics$$c2023$$dQ2
000127583 593__ $$aMolecular Biology$$c2023$$dQ3
000127583 594__ $$a4.5$$b2023
000127583 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000127583 700__ $$0(orcid)0000-0001-7452-0437$$aSainz-DeMena, Diego$$uUniversidad de Zaragoza
000127583 700__ $$0(orcid)0000-0002-3514-6443$$aSánchez, María Teresa
000127583 700__ $$0(orcid)0000-0002-9864-7683$$aGarcía-Aznar, José Manuel$$uUniversidad de Zaragoza
000127583 7102_ $$15004$$2605$$aUniversidad de Zaragoza$$bDpto. Ingeniería Mecánica$$cÁrea Mec.Med.Cont. y Teor.Est.
000127583 773__ $$g39, 11 (2023), e3760 [21 pp.]$$tInternational Journal for Numerical Methods in Biomedical Engineering$$x2040-7939
000127583 8564_ $$s2334103$$uhttps://zaguan.unizar.es/record/127583/files/texto_completo.pdf$$yVersión publicada
000127583 8564_ $$s2299906$$uhttps://zaguan.unizar.es/record/127583/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000127583 909CO $$ooai:zaguan.unizar.es:127583$$particulos$$pdriver
000127583 951__ $$a2024-11-22-12:08:59
000127583 980__ $$aARTICLE