000127632 001__ 127632
000127632 005__ 20230921142939.0
000127632 0247_ $$2doi$$a10.3390/vaccines8010077
000127632 0248_ $$2sideral$$a116796
000127632 037__ $$aART-2020-116796
000127632 041__ $$aeng
000127632 100__ $$aArtigas-Jerónimo, S.
000127632 245__ $$aA novel combined scientific and artistic approach for the advanced characterization of interactomes: The akirin/subolesin model
000127632 260__ $$c2020
000127632 5060_ $$aAccess copy available to the general public$$fUnrestricted
000127632 5203_ $$aThe main objective of this study was to propose a novel methodology to approach challenges in molecular biology. Akirin/Subolesin (AKR/SUB) are vaccine protective antigens and are a model for the study of the interactome due to its conserved function in the regulation of different biological processes such as immunity and development throughout the metazoan. Herein, three visual artists and a music professor collaborated with scientists for the functional characterization of the AKR2 interactome in the regulation of the NF-¿B pathway in human placenta cells. The results served as a methodological proof-of-concept to advance this research area. The results showed new perspectives on unexplored characteristics of AKR2 with functional implications. These results included protein dimerization, the physical interactions with different proteins simultaneously to regulate various biological processes defined by cell type-specific AKR– protein interactions, and how these interactions positively or negatively regulate the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-¿B) signaling pathway in a biological context-dependent manner. These results suggested that AKR2-interacting proteins might constitute suitable secondary transcription factors for cell-and stimulus-specific regulation of NF-¿B. Musical perspective supported AKR/SUB evolutionary conservation in different species and provided new mechanistic insights into the AKR2 interactome. The combined scientific and artistic perspectives resulted in a multidisciplinary approach, advancing our knowledge on AKR/SUB interactome, and provided new insights into the function of AKR2–protein interactions in the regulation of the NF-¿B pathway. Additionally, herein we proposed an algorithm for quantum vaccinomics by focusing on the model proteins AKR/SUB. © 2020 by the authors. Licensee MDPI, Basel, Switzerland.
000127632 536__ $$9info:eu-repo/grantAgreement/ES/MINECO/BFU2016-79892-P
000127632 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000127632 590__ $$a4.422$$b2020
000127632 591__ $$aMEDICINE, RESEARCH & EXPERIMENTAL$$b63 / 140 = 0.45$$c2020$$dQ2$$eT2
000127632 591__ $$aIMMUNOLOGY$$b74 / 162 = 0.457$$c2020$$dQ2$$eT2
000127632 592__ $$a1.296$$b2020
000127632 593__ $$aDrug Discovery$$c2020$$dQ1
000127632 593__ $$aImmunology$$c2020$$dQ1
000127632 593__ $$aPharmacology (medical)$$c2020$$dQ1
000127632 593__ $$aPharmacology$$c2020$$dQ1
000127632 593__ $$aInfectious Diseases$$c2020$$dQ1
000127632 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000127632 700__ $$aPastor Comín, J. J.
000127632 700__ $$aVillar, M.
000127632 700__ $$aContreras, M.
000127632 700__ $$aAlberdi, P.
000127632 700__ $$aViera, I. L.
000127632 700__ $$aSoto, L.
000127632 700__ $$aCordero, R.
000127632 700__ $$aValdés, J. J.
000127632 700__ $$aCabezas-Cruz, A.
000127632 700__ $$0(orcid)0000-0001-7483-046X$$aEstrada-Peña, A.$$uUniversidad de Zaragoza
000127632 700__ $$ade la Fuente, J.
000127632 7102_ $$11009$$2773$$aUniversidad de Zaragoza$$bDpto. Patología Animal$$cÁrea Sanidad Animal
000127632 773__ $$g8, 1 (2020), 77 [27 pp]$$tVaccines$$x2076-393X
000127632 8564_ $$s5851163$$uhttps://zaguan.unizar.es/record/127632/files/texto_completo.pdf$$yVersión publicada
000127632 8564_ $$s2600623$$uhttps://zaguan.unizar.es/record/127632/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000127632 909CO $$ooai:zaguan.unizar.es:127632$$particulos$$pdriver
000127632 951__ $$a2023-09-21-13:01:32
000127632 980__ $$aARTICLE