000127658 001__ 127658
000127658 005__ 20241125101143.0
000127658 0247_ $$2doi$$a10.3390/cimb45090476
000127658 0248_ $$2sideral$$a134767
000127658 037__ $$aART-2023-134767
000127658 041__ $$aeng
000127658 100__ $$0(orcid)0000-0002-2455-680X$$aLópez-Pingarrón, Laura$$uUniversidad de Zaragoza
000127658 245__ $$aPathophysiological implications of interstitial Cajal-like cells (ICC-like) in uterus: A comparative study with gastrointestinal ICCs
000127658 260__ $$c2023
000127658 5060_ $$aAccess copy available to the general public$$fUnrestricted
000127658 5203_ $$aThe main function of interstitial cells of Cajal (ICCs) is to regulate gastrointestinal peristalsis by acting as a “pacemaker” cell by generating spontaneous slow electrical waves. In 2005, electron microscopy revealed a cell type similar to ICCs (ICC-like) outside the gastrointestinal tract, with contractile activity and c-Kit+ immunohistochemistry shared with ICCs. Among the locations where ICC-like cells have been observed, it is in the uterus where they have a significant functional and pathophysiological role. These cells are involved in obstetric phenomena of contractile action, such
as ascending sperm transport, embryo implantation, pregnancy, delivery, and the expulsion of menstrual debris. Within the pathophysiology related to these cells, we find obstetric alterations such as recurrent miscarriages, premature deliveries, abolition of uterine contractions, and failures of
embryo implantation, in addition to other common conditions in the fertile age, such as endometriosis and leiomyoma.
000127658 536__ $$9info:eu-repo/grantAgreement/ES/DGA/B56-23D
000127658 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000127658 590__ $$a2.8$$b2023
000127658 592__ $$a0.675$$b2023
000127658 591__ $$aBIOCHEMISTRY & MOLECULAR BIOLOGY$$b184 / 313 = 0.588$$c2023$$dQ3$$eT2
000127658 593__ $$aMedicine (miscellaneous)$$c2023$$dQ2
000127658 593__ $$aMicrobiology$$c2023$$dQ2
000127658 593__ $$aMicrobiology (medical)$$c2023$$dQ2
000127658 593__ $$aMolecular Biology$$c2023$$dQ3
000127658 594__ $$a2.9$$b2023
000127658 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000127658 700__ $$aAlmeida, Henrique
000127658 700__ $$0(orcid)0000-0002-9357-143X$$aPereboom-Maicas, Matilde Desirée$$uUniversidad de Zaragoza
000127658 700__ $$0(orcid)0000-0001-9507-6478$$aGarcía García, José Joaquín$$uUniversidad de Zaragoza
000127658 7102_ $$11012$$2410$$aUniversidad de Zaragoza$$bDpto. Farmac.Fisiol.y Med.L.F.$$cÁrea Fisiología
000127658 773__ $$g45 (2023), 7557–7571$$pCurr. issues mol. biol.$$tCURRENT ISSUES IN MOLECULAR BIOLOGY$$x1467-3037
000127658 8564_ $$s1798891$$uhttps://zaguan.unizar.es/record/127658/files/texto_completo.pdf$$yVersión publicada
000127658 8564_ $$s2583495$$uhttps://zaguan.unizar.es/record/127658/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000127658 909CO $$ooai:zaguan.unizar.es:127658$$particulos$$pdriver
000127658 951__ $$a2024-11-22-12:03:31
000127658 980__ $$aARTICLE