Resumen: The purpose of the study was to investigate the association between handgrip strength and the incidence of work limitations in European adults aged 50 and older. We conducted a prospective cohort study among adults aged 50 and older from 27 European countries and Israel. Data were collected from the Survey of Health, Ageing and Retirement in Europe (SHARE) waves 1, 2, 4, 5, 6, and 7. Handgrip strength was measured using a hand dynamometer (Smedley, S Dynamometer, TTM) and participants replied to questions about work limitations. Cox regression was conducted for statistical analyses. A total of 70,820 older adults (mean age 61 ± 7.7 years; 54.3 % women) were followed during a mean of 3.8 ± 2.9 years. The fully adjusted model showed that participants with low handgrip strength (<16 kg in women and <27 kg in men) had a significantly higher risk of work limitations compared with participants with normal values of handgrip strength (hazard ratio: 1.36; 95 % confidence interval: 1.28–1.44). Kaplan-Meier trajectories revealed that the survival probability to experience work limitations in the normal handgrip category was 20 % lower than in the low handgrip category in most of the follow-up period. We identified low level of handgrip strength as a risk factor for work limitations in adults aged 50 years or older. This could be used as an accessible measure to screen workers at risk of developing work limitations. Idioma: Inglés DOI: 10.1016/j.maturitas.2023.107798 Año: 2023 Publicado en: Maturitas 177 (2023), 107798 [7 pp.] ISSN: 0378-5122 Factor impacto JCR: 3.9 (2023) Categ. JCR: OBSTETRICS & GYNECOLOGY rank: 15 / 136 = 0.11 (2023) - Q1 - T1 Categ. JCR: GERIATRICS & GERONTOLOGY rank: 24 / 74 = 0.324 (2023) - Q2 - T1 Factor impacto CITESCORE: 9.1 - Obstetrics and Gynecology (Q1) - Biochemistry, Genetics and Molecular Biology (all) (Q1)