000127673 001__ 127673
000127673 005__ 20240731103410.0
000127673 0247_ $$2doi$$a10.3389/fmicb.2023.1247804
000127673 0248_ $$2sideral$$a134648
000127673 037__ $$aART-2023-134648
000127673 041__ $$aeng
000127673 100__ $$aGracia-Ahufinger, Irene
000127673 245__ $$aThe CARBA-MAP study: national mapping of carbapenemases in Spain (2014–2018)
000127673 260__ $$c2023
000127673 5060_ $$aAccess copy available to the general public$$fUnrestricted
000127673 5203_ $$aIntroduction:Infections caused by carbapenem-resistant Enterobacterales (CRE) and carbapenem-resistant Pseudomonas aeruginosa, including isolates producing acquired carbapenemases, constitute a prevalent health problem worldwide. The primary objective of this study was to determine the distribution of the different carbapenemases among carbapenemase-producing Enterobacterales (CPE, specifically Escherichia coli, Klebsiella pneumoniae, Enterobacter cloacae complex, and Klebsiella aerogenes) and carbapenemase-producing P. aeruginosa (CPPA) in Spain from January 2014 to December 2018.Methods: A national, retrospective, cross-sectional multicenter study was performed. The study included the first isolate per patient and year obtained from clinical samples and obtained for diagnosis of infection in hospitalized patients. A structured questionnaire was completed by the participating centers using the REDCap platform, and results were analyzed using IBM SPSS Statistics 29.0.0.Results: A total of 2,704 carbapenemase-producing microorganisms were included, for which the type of carbapenemase was determined in 2692 cases: 2280 CPE (84.7%) and 412 CPPA (15.3%), most often using molecular methods and immunochromatographic assays. Globally, the most frequent types of carbapenemase in Enterobacterales and P. aeruginosa were OXA-48-like, alone or in combination with other enzymes (1,523 cases, 66.8%) and VIM (365 cases, 88.6%), respectively. Among Enterobacterales, carbapenemase-producing K. pneumoniae was reported in 1821 cases (79.9%), followed by E. cloacae complex in 334 cases (14.6%). In Enterobacterales, KPC is mainly present in the South and South-East regions of Spain and OXA-48-like in the rest of the country. Regarding P. aeruginosa, VIM is widely distributed all over the country. Globally, an increasing percentage of OXA-48-like enzymes was observed from 2014 to 2017. KPC enzymes were more frequent in 2017–2018 compared to 2014–2016.Discussion: Data from this study help to understand the situation and evolution of the main species of CPE and CPPA in Spain, with practical implications for control and optimal treatment of infections caused by these multi-drug resistant organisms.
000127673 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000127673 590__ $$a4.0$$b2023
000127673 592__ $$a1.065$$b2023
000127673 591__ $$aMICROBIOLOGY$$b53 / 161 = 0.329$$c2023$$dQ2$$eT1
000127673 593__ $$aMicrobiology (medical)$$c2023$$dQ1
000127673 593__ $$aMicrobiology$$c2023$$dQ1
000127673 594__ $$a7.7$$b2023
000127673 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000127673 700__ $$aLópez-González, Laura
000127673 700__ $$aVasallo, Francisco José
000127673 700__ $$aGalar, Alicia
000127673 700__ $$aSiller, María
000127673 700__ $$aPitart, Cristina
000127673 700__ $$aBloise, Iván
000127673 700__ $$aTorrecillas, Miriam
000127673 700__ $$aGijón-Cordero, Desirée
000127673 700__ $$aViñado, Belén
000127673 700__ $$0(orcid)0000-0002-2519-701X$$aCastillo-García, Javier$$uUniversidad de Zaragoza
000127673 700__ $$aCampo, Rainer
000127673 700__ $$aMulet, Xavier
000127673 700__ $$aMadueño-Alonso, Ana
000127673 700__ $$aChamizo-López, Francisco Javier
000127673 700__ $$aArrastia-Erviti, Maitane
000127673 700__ $$aGalán-Sánchez, Fátima
000127673 700__ $$aFernández-Quejo, Melisa
000127673 700__ $$aRodríguez-Díaz, Juan Carlos
000127673 700__ $$aGutiérrez-Zufiaurre, María Nieves
000127673 700__ $$aRodríguez-Maresca, Manuel Angel
000127673 700__ $$aOrtega-Lafont, María del Pilar
000127673 700__ $$aYagüe-Guirao, Genoveva
000127673 700__ $$aChaves-Blanco, Lucía
000127673 700__ $$aColomina-Rodríguez, Javier
000127673 700__ $$aVidal-Acuña, María Reyes
000127673 700__ $$aPortillo, María Eugenia
000127673 700__ $$aFranco-Álvarez de Luna, Francisco
000127673 700__ $$aCentelles-Serrano, María José
000127673 700__ $$aAzcona-Gutiérrez, José Manuel
000127673 700__ $$aDelgado-Iribarren García Campero, Alberto
000127673 700__ $$aRey-Cao, Sonia
000127673 700__ $$aMuñoz, Patricia
000127673 700__ $$aCalvo-Montes, Jorge
000127673 700__ $$aZboromyrska, Yuliya
000127673 700__ $$aGrandioso, David
000127673 700__ $$aCàmara, Jordi
000127673 700__ $$aCantón, Rafael
000127673 700__ $$aLarrosa-Escartín, Nieves
000127673 700__ $$aDíaz-Regañón, Jazmín
000127673 700__ $$aMartínez-Martínez, Luis
000127673 7102_ $$11011$$2630$$aUniversidad de Zaragoza$$bDpto. Microb.Ped.Radio.Sal.Pú.$$cÁrea Microbiología
000127673 773__ $$g14 (2023), 1247804 [11 pp.]$$pFront. microbiol.$$tFrontiers in Microbiology$$x1664-302X
000127673 8564_ $$s1232948$$uhttps://zaguan.unizar.es/record/127673/files/texto_completo.pdf$$yVersión publicada
000127673 8564_ $$s2652118$$uhttps://zaguan.unizar.es/record/127673/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
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000127673 951__ $$a2024-07-31-10:03:31
000127673 980__ $$aARTICLE