127673 20241125101157.0 doi 10.3389/fmicb.2023.1247804 sideral 134648 ART-2023-134648 eng Gracia-Ahufinger, Irene The CARBA-MAP study: national mapping of carbapenemases in Spain (2014–2018) 2023 Access copy available to the general public Unrestricted Introduction:Infections caused by carbapenem-resistant Enterobacterales (CRE) and carbapenem-resistant Pseudomonas aeruginosa, including isolates producing acquired carbapenemases, constitute a prevalent health problem worldwide. The primary objective of this study was to determine the distribution of the different carbapenemases among carbapenemase-producing Enterobacterales (CPE, specifically Escherichia coli, Klebsiella pneumoniae, Enterobacter cloacae complex, and Klebsiella aerogenes) and carbapenemase-producing P. aeruginosa (CPPA) in Spain from January 2014 to December 2018.Methods: A national, retrospective, cross-sectional multicenter study was performed. The study included the first isolate per patient and year obtained from clinical samples and obtained for diagnosis of infection in hospitalized patients. A structured questionnaire was completed by the participating centers using the REDCap platform, and results were analyzed using IBM SPSS Statistics 29.0.0.Results: A total of 2,704 carbapenemase-producing microorganisms were included, for which the type of carbapenemase was determined in 2692 cases: 2280 CPE (84.7%) and 412 CPPA (15.3%), most often using molecular methods and immunochromatographic assays. Globally, the most frequent types of carbapenemase in Enterobacterales and P. aeruginosa were OXA-48-like, alone or in combination with other enzymes (1,523 cases, 66.8%) and VIM (365 cases, 88.6%), respectively. Among Enterobacterales, carbapenemase-producing K. pneumoniae was reported in 1821 cases (79.9%), followed by E. cloacae complex in 334 cases (14.6%). In Enterobacterales, KPC is mainly present in the South and South-East regions of Spain and OXA-48-like in the rest of the country. Regarding P. aeruginosa, VIM is widely distributed all over the country. Globally, an increasing percentage of OXA-48-like enzymes was observed from 2014 to 2017. KPC enzymes were more frequent in 2017–2018 compared to 2014–2016.Discussion: Data from this study help to understand the situation and evolution of the main species of CPE and CPPA in Spain, with practical implications for control and optimal treatment of infections caused by these multi-drug resistant organisms. info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 4.0 2023 MICROBIOLOGY 53 / 161 = 0.329 2023 Q2 T1 1.065 2023 Microbiology (medical) 2023 Q1 Microbiology 2023 Q1 7.7 2023 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion López-González, Laura Vasallo, Francisco José Galar, Alicia Siller, María Pitart, Cristina Bloise, Iván Torrecillas, Miriam Gijón-Cordero, Desirée Viñado, Belén Castillo-García, Javier Universidad de Zaragoza (orcid)0000-0002-2519-701X Campo, Rainer Mulet, Xavier Madueño-Alonso, Ana Chamizo-López, Francisco Javier Arrastia-Erviti, Maitane Galán-Sánchez, Fátima Fernández-Quejo, Melisa Rodríguez-Díaz, Juan Carlos Gutiérrez-Zufiaurre, María Nieves Rodríguez-Maresca, Manuel Angel Ortega-Lafont, María del Pilar Yagüe-Guirao, Genoveva Chaves-Blanco, Lucía Colomina-Rodríguez, Javier Vidal-Acuña, María Reyes Portillo, María Eugenia Franco-Álvarez de Luna, Francisco Centelles-Serrano, María José Azcona-Gutiérrez, José Manuel Delgado-Iribarren García Campero, Alberto Rey-Cao, Sonia Muñoz, Patricia Calvo-Montes, Jorge Zboromyrska, Yuliya Grandioso, David Càmara, Jordi Cantón, Rafael Larrosa-Escartín, Nieves Díaz-Regañón, Jazmín Martínez-Martínez, Luis 1011 630 Universidad de Zaragoza Dpto. Microb.Ped.Radio.Sal.Pú. Área Microbiología 14 (2023), 1247804 [11 pp.] Front. microbiol. Frontiers in Microbiology 1664-302X 1232948 http://zaguan.unizar.es/record/127673/files/texto_completo.pdf Versión publicada 2652118 http://zaguan.unizar.es/record/127673/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:127673 articulos driver 2024-11-22-12:09:40 ARTICLE