000127674 001__ 127674
000127674 005__ 20231215091008.0
000127674 0247_ $$2doi$$a10.1016/j.cma.2023.116222
000127674 0248_ $$2sideral$$a134737
000127674 037__ $$aART-2023-134737
000127674 041__ $$aeng
000127674 100__ $$aKarami, Mina
000127674 245__ $$aA 3D multi-scale skeletal muscle model to predict active and passive responses. Application to intra-abdominal pressure prediction
000127674 260__ $$c2023
000127674 5060_ $$aAccess copy available to the general public$$fUnrestricted
000127674 5203_ $$aComputational models have been used extensively to study the behavior of skeletal muscle structures, however few of these models are able to evaluate their 3D active response using as input experimental measurements such as electromyography. Hence, improving the activation mechanisms in simulation models can provide interesting and useful achievements in this field. Therefore, the purpose of this paper was to develop a multi-scale chemo-mechanical material model to consider the active behavior of skeletal muscle in 3D geometries. The model was used to investigate the response of abdominal muscles which represent a challenging scenario due to their complex geometry and anatomical conditions. Realistic muscle geometries and other tissues of the human abdomen, including transverse abdominis (TA), internal oblique (IO), external oblique (EO), rectus abdominis (RA), rectus sheath (RSH), linea alba (LA) and aponeurosis (APO) were considered. Since the geometry of these tissues was obtained from magnetic resonance images, an iterative algorithm was implemented to find the initial stress state that achieve the equilibrium of them with the intra-abdominal pressure. In order to investigate the functionality of the proposed model, the increase of intra-abdominal pressure was calculated during cough in the supine position while the Ca2+ signal for activating the muscles was set in regard to experimentally recorded electrical activity from previous studies. The amount of intra-abdominal pressure calculated by the model is consistent with reported experimental results. This model can serve as a virtual laboratory to analyze the role of the abdominal wall components in different conditions, such as the performance of meshes used for repairing hernia defects.
000127674 536__ $$9info:eu-repo/grantAgreement/ES/DGA/T24-23R$$9info:eu-repo/grantAgreement/ES/MICINN/PID2020-113822RB-C21
000127674 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
000127674 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000127674 700__ $$aZohoor, Hassan
000127674 700__ $$0(orcid)0000-0001-9713-1813$$aCalvo, Begoña$$uUniversidad de Zaragoza
000127674 700__ $$0(orcid)0000-0002-6870-0594$$aGrasa, Jorge$$uUniversidad de Zaragoza
000127674 7102_ $$15004$$2605$$aUniversidad de Zaragoza$$bDpto. Ingeniería Mecánica$$cÁrea Mec.Med.Cont. y Teor.Est.
000127674 773__ $$g415 (2023), 116222 [23 pp.]$$pComput. methods appl. mech. eng.$$tComputer Methods in Applied Mechanics and Engineering$$x0045-7825
000127674 8564_ $$s3061977$$uhttps://zaguan.unizar.es/record/127674/files/texto_completo.pdf$$yVersión publicada
000127674 8564_ $$s2187485$$uhttps://zaguan.unizar.es/record/127674/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000127674 909CO $$ooai:zaguan.unizar.es:127674$$particulos$$pdriver
000127674 951__ $$a2023-12-15-09:04:42
000127674 980__ $$aARTICLE