000127685 001__ 127685 000127685 005__ 20241125101157.0 000127685 0247_ $$2doi$$a10.3390/nano13172392 000127685 0248_ $$2sideral$$a134771 000127685 037__ $$aART-2023-134771 000127685 041__ $$aeng 000127685 100__ $$0(orcid)0000-0002-3916-9992$$aAramendía, Maite$$uUniversidad de Zaragoza 000127685 245__ $$aIsotope dilution analysis for particle mass determination using single-particle inductively coupled plasma time-of-flight mass spectrometry: application to size determination of silver nanoparticles 000127685 260__ $$c2023 000127685 5060_ $$aAccess copy available to the general public$$fUnrestricted 000127685 5203_ $$aThis paper describes methodology based on the application of isotope dilution (ID) in single-particle inductively coupled plasma time-of-flight mass spectrometry (spICP-ToFMS) mode for the mass determination (and sizing) of silver nanoparticles (AgNPs). For this purpose, and considering that the analytical signal in spICP-MS shows a transient nature, an isotope dilution equation used for online work was adapted and used for the mass determination of individual NPs. The method proposed measures NP isotope ratios in a particle-to-particle approach, which allows for the characterization of NP mass (and size) distributions and not only the mean size of the distribution. For the best results to be obtained, our method development (undertaken through the analysis of the reference material NIST RM 8017) included the optimization of the working conditions for the best precision and accuracy in isotope ratios of individual NPs, which had been only reported to date with multicollector instruments. It is shown that the precision of the measurement of these ratios is limited by the magnitude of the signals obtained for each NP in the mass analyzer (counting statistics). However, the uncertainty obtained for the sizing of NPs in this approach can be improved by careful method optimization, where the most important parameters are shown to be the selection of the spike isotopic composition and concentration. Although only AgNPs were targeted in this study, the method presented, with the corresponding adaptations, could be applied to NPs of any other composition that include an element with different naturally available isotopes. 000127685 536__ $$9info:eu-repo/grantAgreement/ES/DGA/E43-20R$$9info:eu-repo/grantAgreement/ES/MICINN/PID2021-122455NB-I00 000127685 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/ 000127685 590__ $$a4.4$$b2023 000127685 592__ $$a0.798$$b2023 000127685 591__ $$aMATERIALS SCIENCE, MULTIDISCIPLINARY$$b146 / 439 = 0.333$$c2023$$dQ2$$eT2 000127685 593__ $$aChemical Engineering (miscellaneous)$$c2023$$dQ1 000127685 591__ $$aNANOSCIENCE & NANOTECHNOLOGY$$b62 / 141 = 0.44$$c2023$$dQ2$$eT2 000127685 593__ $$aMaterials Science (miscellaneous)$$c2023$$dQ2 000127685 591__ $$aCHEMISTRY, MULTIDISCIPLINARY$$b70 / 231 = 0.303$$c2023$$dQ2$$eT1 000127685 591__ $$aPHYSICS, APPLIED$$b47 / 179 = 0.263$$c2023$$dQ2$$eT1 000127685 594__ $$a8.5$$b2023 000127685 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion 000127685 700__ $$aLeite, Diego 000127685 700__ $$0(orcid)0000-0002-7532-2720$$aResano, Javier$$uUniversidad de Zaragoza 000127685 700__ $$0(orcid)0000-0002-7450-8769$$aResano, Martín$$uUniversidad de Zaragoza 000127685 700__ $$aBillimoria, Kharmen 000127685 700__ $$aGoenaga-Infante, Heidi 000127685 7102_ $$12009$$2750$$aUniversidad de Zaragoza$$bDpto. Química Analítica$$cÁrea Química Analítica 000127685 7102_ $$15007$$2035$$aUniversidad de Zaragoza$$bDpto. Informát.Ingenie.Sistms.$$cÁrea Arquit.Tecnología Comput. 000127685 773__ $$g13, 17 (2023), 2392 [20 pp.]$$pNanomaterials (Basel)$$tNanomaterials$$x2079-4991 000127685 8564_ $$s3621950$$uhttps://zaguan.unizar.es/record/127685/files/texto_completo.pdf$$yVersión publicada 000127685 8564_ $$s2837771$$uhttps://zaguan.unizar.es/record/127685/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada 000127685 909CO $$ooai:zaguan.unizar.es:127685$$particulos$$pdriver 000127685 951__ $$a2024-11-22-12:09:45 000127685 980__ $$aARTICLE