000127694 001__ 127694
000127694 005__ 20231108202310.0
000127694 0247_ $$2doi$$a10.1016/j.exer.2023.109558
000127694 0248_ $$2sideral$$a134839
000127694 037__ $$aART-2023-134839
000127694 041__ $$aeng
000127694 100__ $$0(orcid)0000-0001-8219-2365$$aCabeza-Gil, Iulen$$uUniversidad de Zaragoza
000127694 245__ $$aViscoelastic properties of porcine lenses using optical coherence elastography and inverse finite element analysis
000127694 260__ $$c2023
000127694 5060_ $$aAccess copy available to the general public$$fUnrestricted
000127694 5203_ $$aThe mechanical properties of the crystalline lens are crucial in determining the changes in lens shape that occur during the accommodation process and are also a major factor in the development of the two most prevalent age-related diseases of the lens, presbyopia and cataracts. However, a comprehensive understanding of these properties is currently lacking. Previous methods for characterizing the mechanical properties of the lens have been limited by the amount of data that could be collected during each test and the lack of complex material modeling. These limitations were mainly caused by the lack of imaging techniques that can provide data for the entire crystalline lens and the need for more complex models to describe the non-linear behavior of the lens. To address these issues, we characterized the mechanical properties of 13 porcine lenses during an ex vivo micro-controlled-displacement compression experiment using optical coherence elastography (OCE) and inverse finite element analysis (iFEA). OCE allowed us to quantify the internal strain distribution of the lens and differentiate between the different parts of the lens, while iFEA enabled us to implement an advanced material model to characterize the viscoelasticity of the lens nucleus and the relative stiffness gradient in the lens. Our findings revealed a pronounced and rapid viscoelastic behavior in the lens nucleus (g1 = 0.39 ± 0.13, τ1 = 5.01 ± 2.31 s) and identified the lens nucleus as the stiffest region, with a stiffness 4.42 ± 1.20 times greater than the anterior cortex and 3.47 ± 0.82 times greater than the posterior cortex. However, due to the complex nature of lens properties, it may be necessary to employ multiple tests simultaneously for a more comprehensive understanding of the crystalline lens.
000127694 536__ $$9This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 956720-OBERON$$9info:eu-repo/grantAgreement/EC/H2020/956720/EU/Opto-Biomechanical Eye Research Network/OBERON
000127694 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
000127694 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000127694 700__ $$aTahsini, Vahoura
000127694 700__ $$aKling, Sabine
000127694 7102_ $$15004$$2605$$aUniversidad de Zaragoza$$bDpto. Ingeniería Mecánica$$cÁrea Mec.Med.Cont. y Teor.Est.
000127694 773__ $$g233 (2023), 109558 [10 pp.]$$pExp. Eye Res.$$tExperimental Eye Research$$x0014-4835
000127694 8564_ $$s6950048$$uhttps://zaguan.unizar.es/record/127694/files/texto_completo.pdf$$yVersión publicada
000127694 8564_ $$s2818170$$uhttps://zaguan.unizar.es/record/127694/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000127694 909CO $$ooai:zaguan.unizar.es:127694$$particulos$$pdriver
000127694 951__ $$a2023-11-08-20:19:54
000127694 980__ $$aARTICLE