000127701 001__ 127701
000127701 005__ 20241125101159.0
000127701 0247_ $$2doi$$a10.1016/j.pbb.2023.173574
000127701 0248_ $$2sideral$$a134750
000127701 037__ $$aART-2023-134750
000127701 041__ $$aeng
000127701 100__ $$aCalpe-López, Claudia
000127701 245__ $$aResilience to the short- and long-term behavioral effects of intermittent repeated social defeat in adolescent male mice
000127701 260__ $$c2023
000127701 5060_ $$aAccess copy available to the general public$$fUnrestricted
000127701 5203_ $$aBackground
Exposure to intermittent repeated social defeat (IRSD) increases the sensitivity of mice to the rewarding effects of cocaine in the conditioned place preference (CPP) paradigm. Some animals are resilient to this effect of IRSD, though research exploring this inconsistency in adolescent mice is scarce. Thus, our aim was to characterize the behavioral profile of mice exposed to IRSD during early adolescence and to explore a potential association with resilience to the short- and long-term effects of IRSD.
Methods
Thirty-six male C57BL/6 mice were exposed to IRSD during early adolescence (PND 27, 30, 33 and 36), while another 10 male mice did not undergo stress (controls). Defeated mice and controls then carried out the following battery of behavioral tests; the Elevated Plus Maze, Hole-Board and Social Interaction Test on PND 37, and the Tail Suspension and Splash tests on PND 38. Three weeks later, all the mice were submitted to the CPP paradigm with a low dose of cocaine (1.5 mg/kg).
Results
IRSD during early adolescence induced depressive-like behavior in the Social Interaction and Splash tests and increased the rewarding effects of cocaine. Mice with low levels of submissive behavior during episodes of defeat were resilient to the short- and long-term effects of IRSD. In addition, resilience to the short-term effects of IRSD on social interaction and grooming behavior predicted resilience to the long-term effects of IRSD on cocaine reward.
Conclusion
Our findings help to characterize the nature of resilience to the effects of social stress during adolescence.
000127701 536__ $$9info:eu-repo/grantAgreement/ES/MICINN/PID2020-118945RB-I00$$9info:eu-repo/grantAgreement/ES/MICINN/PSI2017-83023
000127701 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
000127701 590__ $$a3.3$$b2023
000127701 592__ $$a1.05$$b2023
000127701 591__ $$aBEHAVIORAL SCIENCES$$b8 / 55 = 0.145$$c2023$$dQ1$$eT1
000127701 593__ $$aBehavioral Neuroscience$$c2023$$dQ1
000127701 591__ $$aPHARMACOLOGY & PHARMACY$$b119 / 354 = 0.336$$c2023$$dQ2$$eT2
000127701 593__ $$aBiochemistry$$c2023$$dQ1
000127701 591__ $$aNEUROSCIENCES$$b124 / 310 = 0.4$$c2023$$dQ2$$eT2
000127701 593__ $$aToxicology$$c2023$$dQ1
000127701 593__ $$aClinical Biochemistry$$c2023$$dQ1
000127701 593__ $$aPharmacology$$c2023$$dQ1
000127701 593__ $$aBiological Psychiatry$$c2023$$dQ2
000127701 594__ $$a6.4$$b2023
000127701 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000127701 700__ $$aMartínez-Caballero, Maria Ángeles
000127701 700__ $$aGarcía-Pardo, Maria Pilar$$uUniversidad de Zaragoza
000127701 700__ $$aAguilar, Maria A.
000127701 7102_ $$14009$$2735$$aUniversidad de Zaragoza$$bDpto. Psicología y Sociología$$cÁrea Psicolog.Evolut.Educac
000127701 773__ $$g227-228 (2023), 173574 [12 pp.]$$pPharmacol. biochem. behav.$$tPHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR$$x0091-3057
000127701 8564_ $$s4065457$$uhttps://zaguan.unizar.es/record/127701/files/texto_completo.pdf$$yVersión publicada
000127701 8564_ $$s2547037$$uhttps://zaguan.unizar.es/record/127701/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000127701 909CO $$ooai:zaguan.unizar.es:127701$$particulos$$pdriver
000127701 951__ $$a2024-11-22-12:10:37
000127701 980__ $$aARTICLE