127802 20260223150114.0 doi 10.1038/s41598-023-38084-y sideral 134917 ART-2023-134917 eng Baselga, Marta (orcid)0000-0003-2672-5790 Spheresomes are the main extracellular vesicles in low-grade gliomas 2023 Access copy available to the general public Unrestricted Cancer progression and its impact on treatment response and prognosis is deeply regulated by tumour microenvironment (TME). Cancer cells are in constant communication and modulate TME through several mechanisms, including transfer of tumour-promoting cargos through extracellular vesicles (EVs) or oncogenic signal detection by primary cilia. Spheresomes are a specific EV that arise from rough endoplasmic reticulum–Golgi vesicles. They accumulate beneath cell membrane and are released to the extracellular medium through multivesicular spheres. This study describes spheresomes in low-grade gliomas using electron microscopy. We found that spheresomes are more frequent than exosomes in these tumours and can cross the blood–brain barrier. Moreover, the distinct biogenesis processes of these EVs result in unique cargo profiles, suggesting different functional roles. We also identified primary cilia in these tumours. These findings collectively contribute to our understanding of glioma progression and metastasis. info:eu-repo/grantAgreement/ES/DGA/LMP248_21 info:eu-repo/semantics/openAccess by https://creativecommons.org/licenses/by/4.0/deed.es 3.8 2023 MULTIDISCIPLINARY SCIENCES 25 / 134 = 0.187 2023 Q1 T1 0.9 2023 Multidisciplinary 2023 Q1 7.5 2023 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Iruzubieta, Pablo Castiella, Tomás (orcid)0000-0001-7453-2470 Monzón, Marta Universidad de Zaragoza (orcid)0000-0002-2787-9671 Monleón, Eva Universidad de Zaragoza (orcid)0000-0002-7453-1766 Berga, Carmen Schuhmacher, Alberto J. (orcid)0000-0002-0136-1049 Junquera, Concepción Universidad de Zaragoza (orcid)0000-0002-9951-1075 1003 443 Universidad de Zaragoza Dpto. Anatom.Histolog.Humanas Area Histología 13 (2023), 11180 [11 pp.] Sci. rep. (Nat. Publ. Group) Scientific reports (Nature Publishing Group) 2045-2322 4791113 http://zaguan.unizar.es/record/127802/files/texto_completo.pdf Versión publicada 2672474 http://zaguan.unizar.es/record/127802/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:127802 articulos driver 2026-02-23-14:58:19 ARTICLE