127804 20241125101146.0 doi 10.3390/nu15173775 sideral 134956 ART-2023-134956 eng Kintossou, Ambroise Kouame Early Life Nutrition Factors and Risk of Acute Leukemia in Children: Systematic Review and Meta-Analysis 2023 Access copy available to the general public Unrestricted Acute leukemia commonly occurs in young children with peak incidence at the age of 2–5 years. However, the etiology is still unclear and many preventable risk factors still deserve to be reviewed. The focus of this systematic review and meta-analysis is to summarize the evidence concerning early life nourishment (breastfeeding, early life diet), neonatal vitamin K administration and the risk of acute leukemia. All epidemiological studies published up to June 2023 and assessing diet-related risk factors for childhood acute leukemia were identified in two electronic databases (PubMed and Web of Science), with no limits on publication year or language. A total of 38 studies (37 case–control studies and 1 study with pooled analysis) were included. The published risk estimates were combined into a meta-analysis using the Generic Inverse Variance method. The current evidence shows that breastfeeding (yes vs. no) has a protective effect against acute lymphoblastic leukemia (odds ratio = 0.85; 95% CI, 0.76–0.94). Evidence related to the role of other studied factors (foods and supplements) is inconclusive. Further research into the potential role of diet in early life and the risk of acute leukemia is needed to develop prevention strategies at population level. Review Registration: PROSPERO registration no. CRD42019128937. info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 4.8 2023 NUTRITION & DIETETICS 18 / 114 = 0.158 2023 Q1 T1 1.301 2023 Nutrition and Dietetics 2023 Q1 Food Science 2023 Q1 9.2 2023 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Blanco-Lopez, Jessica Iguacel, Isabel Universidad de Zaragoza (orcid)0000-0003-4242-5464 Pisanu, Silvia Almeida, Claudia Choma Bettega Steliarova-Foucher, Eva Sierens, Ciska Gunter, Marc J. Ladas, Elena J. Barr, Ronald D. Van Herck, Koen Kozlakidis, Zisis Huybrechts, Inge 1006 255 Universidad de Zaragoza Dpto. Fisiatría y Enfermería Área Enfermería 15, 17 (2023), 3775 [15 pp.] Nutrients Nutrients 2072-6643 822653 http://zaguan.unizar.es/record/127804/files/texto_completo.pdf Versión publicada 2691441 http://zaguan.unizar.es/record/127804/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:127804 articulos driver 2024-11-22-12:04:24 ARTICLE