000127811 001__ 127811
000127811 005__ 20240731103410.0
000127811 0247_ $$2doi$$a10.1016/j.envpol.2023.121957
000127811 0248_ $$2sideral$$a134838
000127811 037__ $$aART-2023-134838
000127811 041__ $$aeng
000127811 100__ $$aMérida, Diana María
000127811 245__ $$aPhthalate exposure and the metabolic syndrome: A systematic review and meta-analysis
000127811 260__ $$c2023
000127811 5060_ $$aAccess copy available to the general public$$fUnrestricted
000127811 5203_ $$aPhthalates are chemicals widely used in plastic-based consumer products, and human exposure is universal. They are classified as endocrine disruptors, and specific phthalate metabolites have been associated with an increased risk of cardiometabolic diseases. The aim of this study was to assess the association between phthalate exposure and the metabolic syndrome in the general population. A comprehensive literature search was performed in four databases (Web of Science, Medline, PubMed, and Scopus). We included all the observational studies that evaluate the association between phthalate metabolites and the metabolic syndrome available until January 31st, 2023. Pooled Odds Ratios (OR) and their 95% confidence intervals were calculated by using the inverse-variance weighted method. Nine cross-sectional studies and 25,365 participants aged from 12 to 80 were included. Comparing extreme categories of phthalate exposure, the pooled ORs for the metabolic syndrome were: 1.08 (95% CI, 1.02–1.16, I2 = 28%) for low molecular weight phthalates, and 1.11 (95% CI, 1.07–1.16, I2 = 7%) for high molecular weight phthalates. For individual phthalate metabolites, the pooled ORs that achieved statistical significance were: 1.13 (95% CI, 1.00–1.27, I2 = 24%) for MiBP; 1.89 (95% CI, 1.17–3.07, I2 = 15%) for MMP in men; 1.12 (95% CI, 1.00–1.25, I2 = 22%) for MCOP; 1.09 (95% CI, 0.99–1.20, I2 = 0%) for MCPP; 1.16 (95% CI, 1.05–1.28, I2 = 6%) for MBzP; and 1.16 (95% CI, 1.09–1.24, I2 = 14%) for DEHP (including ΣDEHP and its metabolites). In conclusion, both low molecular weight and high molecular weight phthalates were associated with an 8 and 11% higher prevalence of the MetS, respectively. The exposure to six specific phthalate metabolites was associated with a higher prevalence of the MetS.
000127811 536__ $$9info:eu-repo/grantAgreement/ES/FEDER-FSE/FIS/PI17-1709$$9info:eu-repo/grantAgreement/EC/H2020/801342/EU/ACCIÓ programme to foster mobility of researchers with a focus in applied research and technology transfer/TECNIOspringINDUSTRY$$9This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 801342-801342-TECNIOspringINDUSTRY$$9info:eu-repo/grantAgreement/ES/ISCIII-FEDER/PI20-144
000127811 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc$$uhttp://creativecommons.org/licenses/by-nc/3.0/es/
000127811 590__ $$a7.6$$b2023
000127811 592__ $$a2.132$$b2023
000127811 591__ $$aENVIRONMENTAL SCIENCES$$b37 / 358 = 0.103$$c2023$$dQ1$$eT1
000127811 593__ $$aHealth, Toxicology and Mutagenesis$$c2023$$dQ1
000127811 593__ $$aToxicology$$c2023$$dQ1
000127811 593__ $$aPollution$$c2023$$dQ1
000127811 593__ $$aMedicine (miscellaneous)$$c2023$$dQ1
000127811 594__ $$a16.0$$b2023
000127811 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000127811 700__ $$0(orcid)0000-0003-0604-5042$$aMoreno-Franco, Belén$$uUniversidad de Zaragoza
000127811 700__ $$aMarquès, Montse
000127811 700__ $$aLeón-Latre, Montserrat$$uUniversidad de Zaragoza
000127811 700__ $$0(orcid)0000-0003-3963-0846$$aLaclaustra, Martín$$uUniversidad de Zaragoza
000127811 700__ $$aGuallar-Castillón, Pilar
000127811 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000127811 7102_ $$11011$$2615$$aUniversidad de Zaragoza$$bDpto. Microb.Ped.Radio.Sal.Pú.$$cÁrea Medic.Prevent.Salud Públ.
000127811 773__ $$g333 (2023), 121957 [11 pp.]$$pEnviron. pollut.$$tEnvironmental Pollution$$x0269-7491
000127811 8564_ $$s8261840$$uhttps://zaguan.unizar.es/record/127811/files/texto_completo.pdf$$yVersión publicada
000127811 8564_ $$s2292181$$uhttps://zaguan.unizar.es/record/127811/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000127811 909CO $$ooai:zaguan.unizar.es:127811$$particulos$$pdriver
000127811 951__ $$a2024-07-31-10:03:48
000127811 980__ $$aARTICLE