127825 20250210083428.0 doi 10.3390/ph16081161 sideral 134958 ART-2023-134958 eng Pueyo-Val, Javier Universidad de Zaragoza Reports of Symptoms Associated with Supraventricular Arrhythmias as a Serious Adverse Drug Reaction in the Spanish Pharmacovigilance Database 2023 Access copy available to the general public Unrestricted This study aimed to determine the type of drugs reported as suspected of causing severe supraventricular arrhythmias from the Spanish Human Pharmacovigilance System database. A total of 1053 reports were analysed, of which 526 (50%) were on men and 516 (49%) were on women. The most affected age group was the over-65s, with 593 reports (56%). Of the 1613 drugs, those belonging to the cardiovascular system (ATC Group C) were the most numerous (414 reports, 26%), with digoxin being the most frequent drug (49 reports, 12%). Other common groups were antiinfectives for systemic use (ATC Group J; 306 reports, 19%), antineoplastic and immunomodulating agents (ATC Group L; 198 reports, 12%), and nervous system drugs (ATC Group N; 185 reports, 11%). The most common supraventricular arrhythmia was atrial fibrillation (561 reports, 51%). Regarding outcomes, 730 (66%) patients recovered, 76 (7%) did not recover, 25 (3%) recovered but with sequelae, and 23 (2%) resulted in death. This study revealed that certain drugs have reported to be associated more frequently to supraventricular arrhythmias as serious adverse reactions, especially in the older population. Proper clinical management and effective strategies to ensure medication appropriateness should always be considered to improve patient safety when prescribing drugs. info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 4.3 2023 PHARMACOLOGY & PHARMACY 69 / 354 = 0.195 2023 Q1 T1 CHEMISTRY, MEDICINAL 20 / 72 = 0.278 2023 Q2 T1 0.845 2023 Pharmaceutical Science 2023 Q1 Drug Discovery 2023 Q2 Molecular Medicine 2023 Q2 6.1 2023 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Avedillo-Salas, Ana Universidad de Zaragoza (orcid)0000-0003-2153-0417 Berdún-Viñegra, Pablo Pueyo-Val, Olga María Fanlo-Villacampa, Ana Universidad de Zaragoza (orcid)0000-0001-8064-8138 Navarro-Pemán, Cristina Universidad de Zaragoza (orcid)0000-0002-7239-1966 Lanuza-Giménez, Francisco Javier Universidad de Zaragoza (orcid)0000-0002-6485-1926 Ioakeim-Skoufa, Ignatios Vicente-Romero, Jorge Universidad de Zaragoza (orcid)0000-0003-4629-6743 1012 315 Universidad de Zaragoza Dpto. Farmac.Fisiol.y Med.L.F. Área Farmacología 16, 8 (2023), 1161 [12 pp.] Pharmaceuticals Pharmaceuticals 1424-8247 824592 http://zaguan.unizar.es/record/127825/files/texto_completo.pdf Versión publicada 2678744 http://zaguan.unizar.es/record/127825/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:127825 articulos driver 2025-02-10-08:31:25 ARTICLE