000127826 001__ 127826
000127826 005__ 20240731103412.0
000127826 0247_ $$2doi$$a10.1039/d3dt01159c
000127826 0248_ $$2sideral$$a134964
000127826 037__ $$aART-2023-134964
000127826 041__ $$aeng
000127826 100__ $$aFerrando, Ricardo
000127826 245__ $$aAntibacterial properties of phosphine gold(i) complexes with 5-fluorouracil
000127826 260__ $$c2023
000127826 5060_ $$aAccess copy available to the general public$$fUnrestricted
000127826 5203_ $$aNew gold(I) complexes with coordination to 5-fluorouracil (5-FU), an anticancer drug with antibacterial properties, have been synthesised and characterised, and are the first reported examples of 5-FU–Au compounds. These new complexes show high solution stability, even in the presence of a cysteine derivative, and so were evaluated as antibacterial compounds against model Gram-positive and Gram-negative bacteria. All the complexes show excellent antibacterial activity against Gram-positive B. subtilis, most of them improving the activity of 5-FU alone. Furthermore, these new complexes are also active against Gram-negative E. coli, where [Au(5-FU)(PTA)], the complex with the smallest phosphane, is the most bactericidal, 32 times more active than 5-FU on its own.
000127826 536__ $$9info:eu-repo/grantAgreement/ES/DGA/E07-20R$$9info:eu-repo/grantAgreement/ES/AEI/PID2019-104379RB-C21$$9info:eu-repo/grantAgreement/ES/CSIC/MSCA-IF-ERC$$9info:eu-repo/grantAgreement/EC/H2020/845427/EU/Peptide-functionalized POMs as biofilm disruption agents: searching for synergy in bactericidal materials/PePiPOM$$9This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 845427-PePiPOM$$9info:eu-repo/grantAgreement/ES/MICINN-AEI/RED2018-102471-T
000127826 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc$$uhttp://creativecommons.org/licenses/by-nc/3.0/es/
000127826 590__ $$a3.5$$b2023
000127826 592__ $$a0.697$$b2023
000127826 591__ $$aCHEMISTRY, INORGANIC & NUCLEAR$$b13 / 44 = 0.295$$c2023$$dQ2$$eT1
000127826 593__ $$aInorganic Chemistry$$c2023$$dQ1
000127826 594__ $$a6.6$$b2023
000127826 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000127826 700__ $$0(orcid)0000-0003-4848-414X$$aMitchell, Scott G.
000127826 700__ $$0(orcid)0000-0002-3830-7847$$aAtrián-Blasco, Elena
000127826 700__ $$0(orcid)0000-0003-2457-3674$$aCerrada, Elena$$uUniversidad de Zaragoza
000127826 7102_ $$12010$$2760$$aUniversidad de Zaragoza$$bDpto. Química Inorgánica$$cÁrea Química Inorgánica
000127826 773__ $$g52, 30 (2023), 10507-10514$$pDalton Trans.$$tDalton Transactions$$x1477-9226
000127826 8564_ $$s632431$$uhttps://zaguan.unizar.es/record/127826/files/texto_completo.pdf$$yVersión publicada
000127826 8564_ $$s2724550$$uhttps://zaguan.unizar.es/record/127826/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000127826 909CO $$ooai:zaguan.unizar.es:127826$$particulos$$pdriver
000127826 951__ $$a2024-07-31-10:04:50
000127826 980__ $$aARTICLE