doi:10.1002/chem.201502910engJiménez, M. V.Fernández-Tornos, J.Modrego, F. J.Pérez-Torrente, J. J.Oro, L. A.Oxidation and ß-Alkylation of Alcohols Catalysed by Iridium(I) Complexes with Functionalised N-Heterocyclic Carbene LigandsART-2015-93195The borrowing hydrogen methodology allows for the use of alcohols as alkylating agents for C-C bond forming processes offering significant environmental benefits over traditional approaches. Iridium(I)-cyclooctadiene complexes having a NHC ligand with a O- or N-functionalised wingtip efficiently catalysed the oxidation and ß-alkylation of secondary alcohols with primary alcohols in the presence of a base. The cationic complex Ir(NCCH3)(cod)(MeIm(2- methoxybenzyl))]BF4] (cod=1, 5-cyclooctadiene, MeIm=1-methylimidazolyl) having a rigid O-functionalised wingtip, shows the best catalyst performance in the dehydrogenation of benzyl alcohol in acetone, with an initial turnover frequency (TOF0) of 1283 h-1, and also in the ß-alkylation of 2-propanol with butan-1-ol, which gives a conversion of 94 % in 10 h with a selectivity of 99 % for heptan-2-ol. We have investigated the full reaction mechanism including the dehydrogenation, the cross-aldol condensation and the hydrogenation step by DFT calculations. Interestingly, these studies revealed the participation of the iridium catalyst in the key step leading to the formation of the new C-C bond that involves the reaction of an O-bound enolate generated in the basic medium with the electrophilic aldehyde.2015http://zaguan.unizar.es/record/12787210.1002/chem.201502910http://zaguan.unizar.es/record/127872oai:zaguan.unizar.es:127872info:eu-repo/grantAgreement/ES/MINECO-FEDER/CTQ2013-42532-PChemistry - A European Journal 21, 49 (2015), 17877-17889All rights reservedhttp://www.europeana.eu/rights/rr-f/info:eu-repo/semantics/openAccess