000127886 001__ 127886
000127886 005__ 20240319080959.0
000127886 0247_ $$2doi$$a10.1016/j.bbr.2022.114152
000127886 0248_ $$2sideral$$a132653
000127886 037__ $$aART-2022-132653
000127886 041__ $$aeng
000127886 100__ $$0(orcid)0000-0002-0912-5139$$aAdrián-Ventura, Jesús$$uUniversidad de Zaragoza
000127886 245__ $$aUnderlying differences in resting-state activity metrics related to sensitivity to punishment
000127886 260__ $$c2022
000127886 5060_ $$aAccess copy available to the general public$$fUnrestricted
000127886 5203_ $$aReinforcement sensitivity theory (RST) of personality establishes the punishment sensitivity trait as a source of variation in defensive avoidance/approach behaviors. These individual differences reflect dissimilar sensitivity and reactivity of the fight-flight-freeze and behavioral inhibition systems (FFFS/BIS). The sensitivity to punishment (SP) scale has been widely used in personality research aimed at studying the activity of these systems. Structural and functional neuroimaging studies have confirmed the core biological correlates of FFFS/BIS in humans. Nonetheless, some brain functional features derived from resting-state blood-oxygen level-dependent (BOLD) activity and its association with the punishment sensitivity dimension remain unclear. This relationship would shed light on stable neural activity patterns linked to anxiety-like behaviors and anxiety predisposition. In this study, we analyzed functional activity metrics “at rest” [e.g., regional homogeneity (ReHo) and fractional amplitude of low-frequency fluctuation (fALFF)] and their relationship with SP in key FFFS/BIS regions (e.g., amygdala, hippocampus, and periaqueductal gray) in a sample of 127 healthy adults. Our results revealed a significant negative correlation between the fALFF within all these regions and the scores on SP. Our findings suggest aberrant neural activity (lower fALFF) within the brain’s defense system in participants with high trait anxiety, which in turn could reflect lower FFFS/BIS activation thresholds. These neurally-located differences could lead to pathological fear/anxiety behaviors arising from the FFFS and BIS.
000127886 536__ $$9info:eu-repo/grantAgreement/ES/MEC/FPU15-00825$$9info:eu-repo/grantAgreement/ES/MICINN/PID2019-105077RJ-I00
000127886 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
000127886 590__ $$a2.7$$b2022
000127886 591__ $$aBEHAVIORAL SCIENCES$$b20 / 52 = 0.385$$c2022$$dQ2$$eT2
000127886 591__ $$aNEUROSCIENCES$$b188 / 272 = 0.691$$c2022$$dQ3$$eT3
000127886 592__ $$a0.881$$b2022
000127886 593__ $$aBehavioral Neuroscience$$c2022$$dQ2
000127886 594__ $$a6.2$$b2022
000127886 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000127886 700__ $$aFabregat-Nabás, Jaime
000127886 700__ $$aCostumero, Víctor
000127886 700__ $$aÁvila, César
000127886 7102_ $$14009$$2730$$aUniversidad de Zaragoza$$bDpto. Psicología y Sociología$$cÁrea Psicología Básica
000127886 773__ $$g437 (2022), 114152 [8 pp.]$$pBehav. brain res.$$tBehavioural brain research$$x0166-4328
000127886 8564_ $$s362012$$uhttps://zaguan.unizar.es/record/127886/files/texto_completo.pdf$$yPostprint
000127886 8564_ $$s694948$$uhttps://zaguan.unizar.es/record/127886/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
000127886 909CO $$ooai:zaguan.unizar.es:127886$$particulos$$pdriver
000127886 951__ $$a2024-03-18-13:58:47
000127886 980__ $$aARTICLE