127886 20240319080959.0 doi 10.1016/j.bbr.2022.114152 sideral 132653 ART-2022-132653 eng Adrián-Ventura, Jesús Universidad de Zaragoza (orcid)0000-0002-0912-5139 Underlying differences in resting-state activity metrics related to sensitivity to punishment 2022 Access copy available to the general public Unrestricted Reinforcement sensitivity theory (RST) of personality establishes the punishment sensitivity trait as a source of variation in defensive avoidance/approach behaviors. These individual differences reflect dissimilar sensitivity and reactivity of the fight-flight-freeze and behavioral inhibition systems (FFFS/BIS). The sensitivity to punishment (SP) scale has been widely used in personality research aimed at studying the activity of these systems. Structural and functional neuroimaging studies have confirmed the core biological correlates of FFFS/BIS in humans. Nonetheless, some brain functional features derived from resting-state blood-oxygen level-dependent (BOLD) activity and its association with the punishment sensitivity dimension remain unclear. This relationship would shed light on stable neural activity patterns linked to anxiety-like behaviors and anxiety predisposition. In this study, we analyzed functional activity metrics “at rest” [e.g., regional homogeneity (ReHo) and fractional amplitude of low-frequency fluctuation (fALFF)] and their relationship with SP in key FFFS/BIS regions (e.g., amygdala, hippocampus, and periaqueductal gray) in a sample of 127 healthy adults. Our results revealed a significant negative correlation between the fALFF within all these regions and the scores on SP. Our findings suggest aberrant neural activity (lower fALFF) within the brain’s defense system in participants with high trait anxiety, which in turn could reflect lower FFFS/BIS activation thresholds. These neurally-located differences could lead to pathological fear/anxiety behaviors arising from the FFFS and BIS. info:eu-repo/grantAgreement/ES/MEC/FPU15-00825 info:eu-repo/grantAgreement/ES/MICINN/PID2019-105077RJ-I00 info:eu-repo/semantics/openAccess by-nc-nd http://creativecommons.org/licenses/by-nc-nd/3.0/es/ 2.7 2022 BEHAVIORAL SCIENCES 20 / 52 = 0.385 2022 Q2 T2 NEUROSCIENCES 188 / 272 = 0.691 2022 Q3 T3 0.881 2022 Behavioral Neuroscience 2022 Q2 6.2 2022 info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion Fabregat-Nabás, Jaime Costumero, Víctor Ávila, César 4009 730 Universidad de Zaragoza Dpto. Psicología y Sociología Área Psicología Básica 437 (2022), 114152 [8 pp.] Behav. brain res. Behavioural brain research 0166-4328 362012 http://zaguan.unizar.es/record/127886/files/texto_completo.pdf Postprint 694948 http://zaguan.unizar.es/record/127886/files/texto_completo.jpg?subformat=icon icon Postprint oai:zaguan.unizar.es:127886 articulos driver 2024-03-18-13:58:47 ARTICLE