000127895 001__ 127895
000127895 005__ 20241125101129.0
000127895 0247_ $$2doi$$a10.1039/d3na00229b
000127895 0248_ $$2sideral$$a135124
000127895 037__ $$aART-2023-135124
000127895 041__ $$aeng
000127895 100__ $$aGatti, Lodovico
000127895 245__ $$aPivotal role of the protein corona in the cell uptake of fluorinated nanoparticles with increased sensitivity for19F-MR imaging
000127895 260__ $$c2023
000127895 5060_ $$aAccess copy available to the general public$$fUnrestricted
000127895 5203_ $$aIn vivo cell tracking by non-invasive imaging technologies is needed to accelerate the clinical translation of innovative cell-based therapies. In this regard, 19F-MRI has recently gained increased attention for unbiased localization of labeled cells over time. To push forward the use of 19F-MRI for cell tracking, the development of highly performant 19F-probes is required. PLGA-based NPs containing PERFECTA, a multibranched superfluorinated molecule with an optimal MRI profile thanks to its 36 magnetically equivalent fluorine atoms, are promising 19F-MRI probes. In this work we demonstrate the importance of the surface functionalization of these NPs in relation to their interaction with the biological environment, stressing the pivotal role of the formation of the protein corona (PC) in their cellular labelling efficacy. In particular, our studies showed that the formation of PC NPs strongly promotes the cellular internalization of these NPs in microglia cells. We advocate that the formation of PC NPs in the culture medium can be a key element to be used for the optimization of cell labelling with a considerable increase of the detection sensitivity by 19F-MRI.
000127895 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc$$uhttp://creativecommons.org/licenses/by-nc/3.0/es/
000127895 590__ $$a4.6$$b2023
000127895 592__ $$a0.953$$b2023
000127895 591__ $$aMATERIALS SCIENCE, MULTIDISCIPLINARY$$b141 / 439 = 0.321$$c2023$$dQ2$$eT1
000127895 591__ $$aNANOSCIENCE & NANOTECHNOLOGY$$b60 / 141 = 0.426$$c2023$$dQ2$$eT2
000127895 591__ $$aCHEMISTRY, MULTIDISCIPLINARY$$b69 / 231 = 0.299$$c2023$$dQ2$$eT1
000127895 593__ $$aAtomic and Molecular Physics, and Optics$$c2023$$dQ1
000127895 593__ $$aEngineering (miscellaneous)$$c2023$$dQ1
000127895 593__ $$aMaterials Science (miscellaneous)$$c2023$$dQ1
000127895 593__ $$aChemistry (miscellaneous)$$c2023$$dQ1
000127895 593__ $$aBioengineering$$c2023$$dQ2
000127895 594__ $$a8.0$$b2023
000127895 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000127895 700__ $$aChirizzi, Cristina
000127895 700__ $$aRotta, Giulia
000127895 700__ $$aMilesi, Pietro
000127895 700__ $$0(orcid)0000-0001-8762-5457$$aSancho-Albero, María$$uUniversidad de Zaragoza
000127895 700__ $$0(orcid)0000-0002-6873-5244$$aSebastián, Victor$$uUniversidad de Zaragoza
000127895 700__ $$aMondino, Anna
000127895 700__ $$0(orcid)0000-0002-8701-9745$$aSantamaría, Jesús$$uUniversidad de Zaragoza
000127895 700__ $$aMetrangolo, Pierangelo
000127895 700__ $$aChaabane, Linda
000127895 700__ $$aBaldelli Bombelli, Francesca
000127895 7102_ $$15005$$2555$$aUniversidad de Zaragoza$$bDpto. Ing.Quím.Tecnol.Med.Amb.$$cÁrea Ingeniería Química
000127895 773__ $$g5, 14 (2023), 3749-3760$$tNanoscale Advances$$x2516-0230
000127895 8564_ $$s1029197$$uhttps://zaguan.unizar.es/record/127895/files/texto_completo.pdf$$yVersión publicada
000127895 8564_ $$s2894760$$uhttps://zaguan.unizar.es/record/127895/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000127895 909CO $$ooai:zaguan.unizar.es:127895$$particulos$$pdriver
000127895 951__ $$a2024-11-22-11:58:25
000127895 980__ $$aARTICLE