127911 20241125101137.0 doi 10.3390/bios13100900 sideral 135116 ART-2023-135116 eng Velarte, Antonio Universidad de Zaragoza (orcid)0000-0003-4361-6676 Fiber-Optic-Based System for High-Resolution Monitoring of Stretch in Excised Tissues 2023 Access copy available to the general public Unrestricted Cardiovascular diseases cause a high number of deaths nowadays. To improve these statistics, new strategies to better understand the electrical and mechanical abnormalities underlying them are urgently required. This study focuses on the development of a sensor to measure tissue stretch in excised tissues, enabling improved knowledge of biomechanical properties and allowing greater control in real time. A system made of biocompatible materials is described, which is based on two cantilevered platforms that integrate an optical fiber inside them to quantify the amount of stretch the tissues are exposed to with a precision of μm. The operating principle of the sensor is based on the variation of the optical path with the movement of the platforms onto which the samples are fixed. The conducted tests highlight that this system, based on a simple topology and technology, is capable of achieving the desired purpose (a resolution of ∼1 μm), enabling the tissue to be bathed in any medium within the system. info:eu-repo/grantAgreement/ES/DGA/LMP94_21 info:eu-repo/grantAgreement/ES/DGA/T39-23R info:eu-repo/grantAgreement/EUR/ERC-2014-StG-638284 info:eu-repo/grantAgreement/ES/MICINN/PID2019-105674RB-I00 info:eu-repo/grantAgreement/ES/MICINN/PID2021-127653NB-C21 info:eu-repo/grantAgreement/ES/MICINN/PID2022-140556OB-I00 info:eu-repo/grantAgreement/ES/MICINN/RTI2018-100773-B-C31 info:eu-repo/grantAgreement/EUR/MICINN/TED2021-130459B-I00 info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 4.9 2023 CHEMISTRY, ANALYTICAL 19 / 106 = 0.179 2023 Q1 T1 INSTRUMENTS & INSTRUMENTATION 13 / 76 = 0.171 2023 Q1 T1 NANOSCIENCE & NANOTECHNOLOGY 50 / 141 = 0.355 2023 Q2 T2 0.707 2023 Instrumentation 2023 Q1 Biomedical Engineering 2023 Q2 Medicine (miscellaneous) 2023 Q2 Clinical Biochemistry 2023 Q2 Analytical Chemistry 2023 Q2 Biotechnology 2023 Q2 6.6 2023 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Otin, Aranzazu Universidad de Zaragoza (orcid)0000-0003-1403-1505 Giménez-Gómez, Pablo Muñoz-Berbel, Xavier Pueyo, Esther Universidad de Zaragoza (orcid)0000-0002-1960-407X 5008 785 Universidad de Zaragoza Dpto. Ingeniería Electrón.Com. Área Tecnología Electrónica 5008 800 Universidad de Zaragoza Dpto. Ingeniería Electrón.Com. Área Teoría Señal y Comunicac. 13, 10 (2023), 900 [13 pp.] Biosensors 2079-6374 6954570 http://zaguan.unizar.es/record/127911/files/texto_completo.pdf Versión publicada 2644171 http://zaguan.unizar.es/record/127911/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:127911 articulos driver 2024-11-22-12:01:16 ARTICLE