000127914 001__ 127914
000127914 005__ 20241125101144.0
000127914 0247_ $$2doi$$a10.1002/ueg2.12446
000127914 0248_ $$2sideral$$a135019
000127914 037__ $$aART-2023-135019
000127914 041__ $$aeng
000127914 100__ $$0(orcid)0000-0001-5932-2889$$aLanas, Ángel$$uUniversidad de Zaragoza
000127914 245__ $$aFecal occult blood and calprotectin testing to prioritize primary care patients for colonoscopy referral: The advantage study
000127914 260__ $$c2023
000127914 5060_ $$aAccess copy available to the general public$$fUnrestricted
000127914 5203_ $$aAbstractColonoscopy is the gold standard for colorectal cancer (CRC) diagnosis and screening, but endoscopy services are usually overburdened. This study aims to investigate the usefulness of fecal hemoglobin (fHb) and calprotectin (FC) for the identification of patients with high probability of CRC who need urgent referral.MethodsIn a multicenter prospective study, we enrolled symptomatic patients referred from primary care for colonoscopy. Prior to bowel preparation, fHb and FC quantitative tests were performed. The diagnostic performance was estimated for each biomarker/combination. We built a multivariable predictive model based on logistic regression, translated to a nomogram and a risk calculator to assist clinicians in the decision‐making process.ResultsThe study included 1224 patients, of whom 69 (5.6%) had CRC. At the fHb cut‐offs of >0 and 10 μg/g, the negative predictive values for CRC were 98.8% (95% confidence interval 97.8%–99.3%) and 98.6% (95%CI 97.7%–99.1%), and the sensitivities were 85.5% (95%CI 75.0%–92.8%) and 79.7% (95%CI 68.3%–88.4%), respectively. When we added the cut‐off of 150 μg/g of FC to both fHb thresholds, the sensitivity of fecal tests improved. In the multivariate logistic regression model, the concentration of fHb was an independent predictor for CRC; age and gender were also independently associated with CRC.ConclusionsfHb and FC are useful as part of a triage tool to identify those symptomatic patients with high probability of CRC. This can be easily applied by physicians to prioritize high‐risk patients for urgent colonoscopy.
000127914 536__ $$9info:eu-repo/grantAgreement/ES/ISCIII/PI16-00766$$9info:eu-repo/grantAgreement/ES/ISCIII/PI19-01867
000127914 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
000127914 590__ $$a5.8$$b2023
000127914 592__ $$a1.612$$b2023
000127914 591__ $$aGASTROENTEROLOGY & HEPATOLOGY$$b23 / 143 = 0.161$$c2023$$dQ1$$eT1
000127914 593__ $$aOncology$$c2023$$dQ1
000127914 593__ $$aGastroenterology$$c2023$$dQ1
000127914 594__ $$a10.5$$b2023
000127914 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000127914 700__ $$aBalaguer, Francesc
000127914 700__ $$aSánchez-Luengo, Marta
000127914 700__ $$aHijos-Mallada, Gonzalo$$uUniversidad de Zaragoza
000127914 700__ $$aHernández-Mesa, Goretti
000127914 700__ $$aPiñero, Melisa
000127914 700__ $$aCastillo, Joaquin
000127914 700__ $$aOcaña, Teresa
000127914 700__ $$aCubiella, Joaquín
000127914 700__ $$aCrespo, Anais
000127914 700__ $$aIglesias, Águeda
000127914 700__ $$aMedeiros, Isabel
000127914 700__ $$aCacho, Guillermo
000127914 700__ $$aJover-Martínez, Rodrigo
000127914 700__ $$aAlustiza, Miren
000127914 700__ $$aDiaz-Tasende, José
000127914 700__ $$aPoves, Carmen
000127914 700__ $$aMacedo, Guilherme
000127914 700__ $$aQuintero, Enrique
000127914 700__ $$a
000127914 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000127914 773__ $$g11, 7 (2023), 692-699$$pUnited European Gastroenterol. j.$$tUnited European Gastroenterology Journal$$x2050-6406
000127914 8564_ $$s1206311$$uhttps://zaguan.unizar.es/record/127914/files/texto_completo.pdf$$yVersión publicada
000127914 8564_ $$s2903794$$uhttps://zaguan.unizar.es/record/127914/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000127914 909CO $$ooai:zaguan.unizar.es:127914$$particulos$$pdriver
000127914 951__ $$a2024-11-22-12:03:39
000127914 980__ $$aARTICLE