000127923 001__ 127923
000127923 005__ 20241125101144.0
000127923 0247_ $$2doi$$a10.4067/S0717-95022023000300901
000127923 0248_ $$2sideral$$a135083
000127923 037__ $$aART-2023-135083
000127923 041__ $$aeng
000127923 100__ $$aCintora-López, Patricia
000127923 245__ $$aHistological Evaluation of the Effect of Alendronate on the Maxillary Bone of Wistar Rats Combined with Orthodontic Movement of Intense Force
000127923 260__ $$c2023
000127923 5060_ $$aAccess copy available to the general public$$fUnrestricted
000127923 5203_ $$aTo evaluate the histological adverse effects of alendronate administered systemically and topically in combination with orthodontic movement by intense force. Thirty-six 24-week-old female Wistar rats, ovariectomized, were used and divided into three groups (n = 12/group): control, locally treated with saline (0.07 ml/kg/week) (group 1) and experimental, treated with alendronic acid systemically (0.07 mg/kg/week) (group 2) and locally (7 mg/kg/week) (group 3). At 14 days, an orthodontic anchor was installed in the right first molar, and a force of 144 cN was applied for 28 days. The samples were processed for histological evaluation. Descriptive statistics, Shapiro-Wilk tests, one-way ANOVA with Bonferroni correction, one-way repeated measures ANOVA and chi-square tests were performed. All tests were statistically significant at p <0.05. The adverse events found in all groups were inflammation and osteoclastic activity. In the bisphosphonate-treated groups, there were statistically significant differences (p = 0.005) in the osteoclastic activity between the two hemiarcates. All rats in group 2 presented paralytic ileus. Compared to local administration, systemic treatment with alendronic acid produces more adverse effects, such as inflammation, fibrinoid necrosis, and osteoclastic activity. During the application of intense forces, it was not possible to show that there is necrosis associated with bisphosphonates.
000127923 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc$$uhttp://creativecommons.org/licenses/by-nc/3.0/es/
000127923 590__ $$a0.4$$b2023
000127923 592__ $$a0.191$$b2023
000127923 591__ $$aANATOMY & MORPHOLOGY$$b20 / 22 = 0.909$$c2023$$dQ4$$eT3
000127923 593__ $$aAnatomy$$c2023$$dQ3
000127923 594__ $$a0.9$$b2023
000127923 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000127923 700__ $$aRojo, Rosa
000127923 700__ $$aPastor-Oliver, Cristina
000127923 700__ $$aWhite, Ana
000127923 773__ $$g41, 3 (2023), 901-909$$pInt. J. Morphol.$$tINTERNATIONAL JOURNAL OF MORPHOLOGY$$x0717-9367
000127923 8564_ $$s495319$$uhttps://zaguan.unizar.es/record/127923/files/texto_completo.pdf$$yVersión publicada
000127923 8564_ $$s2403119$$uhttps://zaguan.unizar.es/record/127923/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000127923 909CO $$ooai:zaguan.unizar.es:127923$$particulos$$pdriver
000127923 951__ $$a2024-11-22-12:03:50
000127923 980__ $$aARTICLE