128008 20241125101126.0 doi 10.1080/21691401.2023.2253534 sideral 135181 ART-2023-135181 eng Fernández-Carro, E. Universidad de Zaragoza Nanoparticles Stokes radius assessment through permeability coefficient determination within a new stratified epithelium on-chip model 2023 Access copy available to the general public Unrestricted Tissue barrier permeability plays a crucial role in determining the selective transport of substances across epithelial tissues, including drugs, cosmetic substances, and chemicals. The ability of these substances to cross through tissue barriers affects their absorption into the bloodstream and ultimately their effectiveness. Therefore, the determination of their permeability on these type of tissue barriers represents a useful tool for pharmaceutical and cosmetic industries as well as for toxicological studies. In this regard, microfluidic devices and organ-on-chip technologies are becoming more important to generate reliable data. We have designed and performed an alternative new stratified epithelia-on-chip model that allows to correlate the Stokes radius and the diffusion of molecules and/or nanoformulations through the in vitro generated barrier and establish a system suitable for the analysis of diffusion through stratified epithelium. Thus, extrapolating from experimental data we can predict the Stokes radius for unknown fluorescent labelled particles within a molecular size range, such as gold nanoparticles. info:eu-repo/grantAgreement/ES/DGA/LMP233_21 info:eu-repo/semantics/openAccess by-nc http://creativecommons.org/licenses/by-nc/3.0/es/ 4.5 2023 BIOTECHNOLOGY & APPLIED MICROBIOLOGY 34 / 174 = 0.195 2023 Q1 T1 MATERIALS SCIENCE, BIOMATERIALS 22 / 53 = 0.415 2023 Q2 T2 ENGINEERING, BIOMEDICAL 35 / 123 = 0.285 2023 Q2 T1 0.646 2023 Biomedical Engineering 2023 Q2 Pharmaceutical Science 2023 Q2 Medicine (miscellaneous) 2023 Q2 Biotechnology 2023 Q2 10.9 2023 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Salomón-Cambero, R. Armero, L. Castro-Abril, H. A. Ayensa-Jiménez, J. (orcid)0000-0003-2564-6038 Martínez, Miguel A. Universidad de Zaragoza (orcid)0000-0002-8375-0354 Ochoa, I. Universidad de Zaragoza (orcid)0000-0003-2410-5678 Alcaine, C. Universidad de Zaragoza (orcid)0000-0002-7854-8856 García, I. Ciriza, J. Universidad de Zaragoza (orcid)0000-0002-8666-622X 1006 255 Universidad de Zaragoza Dpto. Fisiatría y Enfermería Área Enfermería 1003 443 Universidad de Zaragoza Dpto. Anatom.Histolog.Humanas Area Histología 5004 605 Universidad de Zaragoza Dpto. Ingeniería Mecánica Área Mec.Med.Cont. y Teor.Est. 51, 1 (2023), 466-475 Artificial Cells Nanomedicine and Biotechnology 2169-1401 2649570 http://zaguan.unizar.es/record/128008/files/texto_completo.pdf Versión publicada 1276702 http://zaguan.unizar.es/record/128008/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:128008 articulos driver 2024-11-22-11:57:42 ARTICLE