000128019 001__ 128019
000128019 005__ 20241125101144.0
000128019 0247_ $$2doi$$a10.1111/eci.14081
000128019 0248_ $$2sideral$$a135151
000128019 037__ $$aART-2023-135151
000128019 041__ $$aeng
000128019 100__ $$aSeral-Cortes, Miguel
000128019 245__ $$aThe body mass index increases the genetic risk scores' ability to predict risk of hepatic damage in European adolescents: The HELENA study
000128019 260__ $$c2023
000128019 5060_ $$aAccess copy available to the general public$$fUnrestricted
000128019 5203_ $$aBackground
Hepatic disorders are often complex and multifactorial, modulated by genetic and environmental determinants. During the last years, the hepatic disease has been progressively established from early stages in life. The use of genetic risk scores (GRS) to predict the genetic susceptibility to a particular phenotype among youth has gained interest in recent years. Moreover, the alanine aminotransferase (ALT) blood biomarker is often considered as hepatic screening tool, in combination with imaging techniques. The aim of the present study was to develop an ALT-specific GRS to help in the evaluation of hepatic damage risk in European adolescents.
Methods
A total of 972 adolescents (51.3% females), aged 12.5–17.5 years, from the Healthy Lifestyle in Europe by Nutrition in Adolescence study were included in the analyses. The sample incorporated adolescents in all body mass index (BMI) categories and was divided considering healthy/unhealthy ALT levels, using sex-specific cut-off points. From 1212 a priori ALT-related single nucleotide polymorphisms (SNPs) extracted from candidate gene selection, a first screening of 234 SNPs univariately associated was established, selecting seven significant SNPs (p < .05) in the multivariate model. An unweighted GRS (uGRS) was developed by summing the number of reference alleles, and a weighted GRS (wGRS), by multiplying each allele to its estimated coefficient.
Results
The uGRS and wGRS were significantly associated with ALT (p < .001). The area under curve was obtained integrating BMI as clinical factor, improving the predictive ability for uGRS (.7039) and wGRS (.7035), using 10-fold internal cross-validation.
Conclusions
Considering BMI status, both GRSs could contribute as complementary tools to help in the early diagnosis of hepatic damage risk in European adolescents.
000128019 536__ $$9info:eu-repo/grantAgreement/EUR/FP6/FOOD-CT-2005-007034$$9info:eu-repo/grantAgreement/EC/H2020/101030971/EU/Human climate adaptation and implications for health/ClimAHealth$$9This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 101030971-ClimAHealth$$9info:eu-repo/grantAgreement/EC/H2020/801586/EU/International Doctoral Programme for Talent Attraction to the Campus of International Excellence of the Ebro Valley/IberusTalent$$9This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 801586-IberusTalent
000128019 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
000128019 590__ $$a4.4$$b2023
000128019 592__ $$a1.27$$b2023
000128019 591__ $$aMEDICINE, GENERAL & INTERNAL$$b37 / 329 = 0.112$$c2023$$dQ1$$eT1
000128019 593__ $$aBiochemistry$$c2023$$dQ1
000128019 591__ $$aMEDICINE, RESEARCH & EXPERIMENTAL$$b57 / 189 = 0.302$$c2023$$dQ2$$eT1
000128019 593__ $$aMedicine (miscellaneous)$$c2023$$dQ1
000128019 593__ $$aClinical Biochemistry$$c2023$$dQ1
000128019 594__ $$a9.5$$b2023
000128019 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000128019 700__ $$aSabroso-Lasa, Sergio
000128019 700__ $$aGonzalez-Gross, Marcela
000128019 700__ $$aQuesada-Gonzalez, Carlos
000128019 700__ $$aStehle, Peter
000128019 700__ $$aGottrand, Frederic
000128019 700__ $$aMarcos, Ascension
000128019 700__ $$aEsperanza-Diaz, Ligia
000128019 700__ $$aManios, Yannis
000128019 700__ $$aAndroutsos, Odysseas
000128019 700__ $$aWidhalm, Kurt
000128019 700__ $$aMolnar, Denes
000128019 700__ $$aHuybrechts, Inge
000128019 700__ $$aMuntaner, Manon
000128019 700__ $$aMeirhaeghe, Aline
000128019 700__ $$aSalazar-Tortosa, Diego
000128019 700__ $$aRuiz, Jonatan R.
000128019 700__ $$0(orcid)0000-0002-3007-302X$$aEsteban, Luis Mariano
000128019 700__ $$aLabayen, Idoia
000128019 700__ $$aMoreno, Luis A.
000128019 700__ $$a
000128019 773__ $$g53, 12 (2023), e14081 [12 pp.]$$pEur. j. clin. investig.$$tEUROPEAN JOURNAL OF CLINICAL INVESTIGATION$$x0014-2972
000128019 8564_ $$s983358$$uhttps://zaguan.unizar.es/record/128019/files/texto_completo.pdf$$yVersión publicada
000128019 8564_ $$s2288072$$uhttps://zaguan.unizar.es/record/128019/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000128019 909CO $$ooai:zaguan.unizar.es:128019$$particulos$$pdriver
000128019 951__ $$a2024-11-22-12:03:56
000128019 980__ $$aARTICLE