000128033 001__ 128033
000128033 005__ 20250124211553.0
000128033 0247_ $$2doi$$a10.1080/01652176.2023.2243309
000128033 0248_ $$2sideral$$a135167
000128033 037__ $$aART-2023-135167
000128033 041__ $$aeng
000128033 100__ $$0(orcid)0000-0003-2957-1379$$aVerde, María Teresa$$uUniversidad de Zaragoza
000128033 245__ $$aNon-controlled, open-label trial to assess clinical and immunological parameters in atopic dogs feeding monoprotein grain free diet versus a standard grain diet
000128033 260__ $$c2023
000128033 5060_ $$aAccess copy available to the general public$$fUnrestricted
000128033 5203_ $$aCanine atopic dermatitis (cAD) is a common inflammatory skin disease that is treated with medicines or allergen-specific immunotherapy. An improvement diet can help treatment of cAD. The purpose of this study was compare two diets on clinical and immunological parameters in atopic dogs without food hypersensitivity. Diet A, a commercial based on rice, was offered to 22 atopic dogs during 30 days and Diet B (grain free, rich in salmon) was given to 8 atopic dogs. Clinical scores were assessed by CADESI-4 and PVAS at the beginning (T0) and at the end of the study (T30). CD4+ and CD8+ were measured in PBMCs, and serum cytokines (TNF-α, IL-10, IL-31 and IL-34) were determined. Both diets decreased CADESI-4 score and Diet A decreased PVAS score (p < 0.05). There were no statistical significant differences between diets at T30 for CD4+ and CD8+. A decrease in the IL-31 concentrations and increase in IL-10 levels (p < 0.05) was observed with Diet A at T30. There were no differences between any of the two diets when the other results at T0 and T30 were compared for any of the parameters analysed. In conclusion, the results indicate that dietary intervention had not influence on cellular component of the immune system, but a positive effect was observed on IL-31, IL-10 serum levels for Diet A. Further studies are needed to enrich dietary components of the food for atopic dogs without food hypersensibility to help improvement the management of the cAD.
000128033 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc$$uhttp://creativecommons.org/licenses/by-nc/3.0/es/
000128033 590__ $$a7.9$$b2023
000128033 592__ $$a1.26$$b2023
000128033 591__ $$aVETERINARY SCIENCES$$b2 / 167 = 0.012$$c2023$$dQ1$$eT1
000128033 593__ $$aVeterinary (miscellaneous)$$c2023$$dQ1
000128033 593__ $$aMedicine (miscellaneous)$$c2023$$dQ1
000128033 594__ $$a13.1$$b2023
000128033 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000128033 700__ $$0(orcid)0000-0001-6209-4282$$aVillanueva-Saz, Sergio$$uUniversidad de Zaragoza
000128033 700__ $$0(orcid)0000-0002-0540-734X$$aNavarro, Laura$$uUniversidad de Zaragoza
000128033 700__ $$0(orcid)0000-0002-1934-5397$$aLoste, Araceli$$uUniversidad de Zaragoza
000128033 700__ $$aMarteles, Diana$$uUniversidad de Zaragoza
000128033 700__ $$0(orcid)0000-0002-2557-4890$$aFernández, Antonio$$uUniversidad de Zaragoza
000128033 700__ $$0(orcid)0000-0002-9357-143X$$aPereboom, Desirée$$uUniversidad de Zaragoza
000128033 7102_ $$11012$$2410$$aUniversidad de Zaragoza$$bDpto. Farmac.Fisiol.y Med.L.F.$$cÁrea Fisiología
000128033 7102_ $$11009$$2617$$aUniversidad de Zaragoza$$bDpto. Patología Animal$$cÁrea Medicina y Cirugía Animal
000128033 773__ $$g43, 1 (2023), 7$$pVet. q.$$tVETERINARY QUARTERLY$$x0165-2176
000128033 8564_ $$s559607$$uhttps://zaguan.unizar.es/record/128033/files/texto_completo.pdf$$yVersión publicada
000128033 8564_ $$s2966648$$uhttps://zaguan.unizar.es/record/128033/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000128033 909CO $$ooai:zaguan.unizar.es:128033$$particulos$$pdriver
000128033 951__ $$a2025-01-24-21:14:53
000128033 980__ $$aARTICLE