000128035 001__ 128035
000128035 005__ 20241125101201.0
000128035 0247_ $$2doi$$a10.1016/j.bbr.2023.114662
000128035 0248_ $$2sideral$$a135183
000128035 037__ $$aART-2023-135183
000128035 041__ $$aeng
000128035 100__ $$aZorzo, Candela
000128035 245__ $$aHippocampal alterations after SARS-CoV-2 infection: a systematic review
000128035 260__ $$c2023
000128035 5060_ $$aAccess copy available to the general public$$fUnrestricted
000128035 5203_ $$aSARS-CoV-2 infection produces a wide range of symptoms. Some of the structural changes caused by the virus in the nervous system are found in the medial temporal lobe, and several neuropsychological sequelae of COVID-19 are related to the function of the hippocampus. The main objective of the systematic review is to update and further analyze the existing evidence of hippocampal and related cortices’ structural and functional alterations due to SARS-CoV-2 infection. Both clinical and preclinical studies that used different methodologies to explore the effects of this disease at different stages and grades of severity were considered, besides exploring related cognitive and emotional symptomatology. A total of 24 studies were identified by searching in SCOPUS, Web Of Science (WOS), PubMed, and PsycInfo databases up to October 3rd, 2022. Thirteen studies were performed in clinical human samples, 9 included preclinical animal models, 3 were performed post-mortem, and 1 included both post-mortem and preclinical samples. Alterations in the hippocampus were detected in the acute stage and after several months of infection. Clinical studies revealed alterations in hippocampal connectivity and metabolism. Memory alterations correlated with altered metabolic profiles or changes in grey matter volumes. Hippocampal human postmortem and animal studies observed alterations in neurogenesis, dendrites, and immune response, besides high apoptosis and neuroinflammation. Preclinical studies reported the viral load in the hippocampus. Olfactory dysfunction was associated with alterations in brain functionality. Several clinical studies revealed cognitive complaints, neuropsychological alterations, and depressive and anxious symptomatology.
000128035 536__ $$9info:eu-repo/grantAgreement/ES/DGA/S31-23R
000128035 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc$$uhttp://creativecommons.org/licenses/by-nc/3.0/es/
000128035 590__ $$a2.6$$b2023
000128035 592__ $$a0.897$$b2023
000128035 591__ $$aBEHAVIORAL SCIENCES$$b15 / 55 = 0.273$$c2023$$dQ2$$eT1
000128035 593__ $$aBehavioral Neuroscience$$c2023$$dQ2
000128035 591__ $$aNEUROSCIENCES$$b176 / 310 = 0.568$$c2023$$dQ3$$eT2
000128035 594__ $$a5.6$$b2023
000128035 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000128035 700__ $$aSolares, Lucía
000128035 700__ $$aMéndez, Marta
000128035 700__ $$0(orcid)0000-0002-4249-602X$$aMéndez-López, Magdalena$$uUniversidad de Zaragoza
000128035 7102_ $$14009$$2725$$aUniversidad de Zaragoza$$bDpto. Psicología y Sociología$$cÁrea Psicobiología
000128035 773__ $$g455 (2023), 114662 [18 pp.]$$pBehav. brain res.$$tBehavioural brain research$$x0166-4328
000128035 8564_ $$s1035118$$uhttps://zaguan.unizar.es/record/128035/files/texto_completo.pdf$$yVersión publicada
000128035 8564_ $$s2970038$$uhttps://zaguan.unizar.es/record/128035/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000128035 909CO $$ooai:zaguan.unizar.es:128035$$particulos$$pdriver
000128035 951__ $$a2024-11-22-12:11:35
000128035 980__ $$aARTICLE