000128037 001__ 128037
000128037 005__ 20241125101201.0
000128037 0247_ $$2doi$$a10.1016/j.livsci.2023.105310
000128037 0248_ $$2sideral$$a135192
000128037 037__ $$aART-2023-135192
000128037 041__ $$aeng
000128037 100__ $$aMartínez-Castillero, María
000128037 245__ $$aIdentification of genomic regions associated with reproductive longevity in the Rubia Gallega beef cattle breed using a censored threshold model
000128037 260__ $$c2023
000128037 5060_ $$aAccess copy available to the general public$$fUnrestricted
000128037 5203_ $$aIn beef cattle, the economic viability of farms is heavily influenced by the cow's ability to survive subsequent pregnancies. To understand the genetic basis of reproductive longevity in Rubia Gallega beef cattle breed, a ssGWAS was performed by back-solving the output of ssGBLUP under a censored threshold model. It considers the number of parities each cow reaches during its productive life as a phenotypic trait. The results of the study showed that the main source of variation of reproductive longevity is the herd. However, the posterior mean of the heritability of reproductive longevity was 0.173, indicating the potential for an appropriate genetic response to selection. Furthermore, it is shown that four genomic regions in chromosomes 2, 11 and 29 explain a large proportion of the additive genetic variance. The most important signal was detected on chromosome 2 in the vicinity of the MSTN (myostatin) gene that is associated with double muscling, and that it is segregating in the Rubia Gallega population. Some other interesting genes located within these regions encoded for several PAGs (Pregnancy-associated glycoprotein), LHCGR (luteinizing hormone/choriogonadotropin receptor), FSHR (follicle stimulating hormone receptor), PROKR1 (prokineticin receptor 1) and EHD3 (Eps15 homology domain-containing protein 3). This confirms the relevance of the reproductive performance in the reproductive longevity of cows. These findings provide valuable insights for the Rubia Gallega breeding program, as they can be used to define future selection strategies to improve reproductive longevity of the breed.
000128037 536__ $$9info:eu-repo/grantAgreement/EUR/FEADER/2019-053A
000128037 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc$$uhttp://creativecommons.org/licenses/by-nc/3.0/es/
000128037 590__ $$a1.8$$b2023
000128037 592__ $$a0.557$$b2023
000128037 591__ $$aAGRICULTURE, DAIRY & ANIMAL SCIENCE$$b25 / 80 = 0.312$$c2023$$dQ2$$eT1
000128037 593__ $$aVeterinary (miscellaneous)$$c2023$$dQ1
000128037 593__ $$aAnimal Science and Zoology$$c2023$$dQ1
000128037 594__ $$a4.3$$b2023
000128037 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000128037 700__ $$aLópez-Carbonell, David$$uUniversidad de Zaragoza
000128037 700__ $$aSrihi, Houssemeddine$$uUniversidad de Zaragoza
000128037 700__ $$aHervás-Rivero, Carlos$$uUniversidad de Zaragoza
000128037 700__ $$0(orcid)0000-0002-3042-2250$$aAltarriba, Juan$$uUniversidad de Zaragoza
000128037 700__ $$aMartínez, Paulino
000128037 700__ $$aHermida, Miguel
000128037 700__ $$0(orcid)0000-0001-6256-5478$$aVarona, Luis$$uUniversidad de Zaragoza
000128037 7102_ $$11001$$2420$$aUniversidad de Zaragoza$$bDpto. Anatom.,Embri.Genét.Ani.$$cÁrea Genética
000128037 773__ $$g276 (2023), 105310 [6 pp.]$$pLivest. Sci.$$tLivestock Science$$x1871-1413
000128037 8564_ $$s1897516$$uhttps://zaguan.unizar.es/record/128037/files/texto_completo.pdf$$yVersión publicada
000128037 8564_ $$s2209323$$uhttps://zaguan.unizar.es/record/128037/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000128037 909CO $$ooai:zaguan.unizar.es:128037$$particulos$$pdriver
000128037 951__ $$a2024-11-22-12:11:36
000128037 980__ $$aARTICLE