000128077 001__ 128077
000128077 005__ 20240319081031.0
000128077 0247_ $$2doi$$a10.1017/S0033291722001544
000128077 0248_ $$2sideral$$a135281
000128077 037__ $$aART-2022-135281
000128077 041__ $$aeng
000128077 100__ $$aSegura, Alex G.
000128077 245__ $$aLink between cognitive polygenic risk scores and clinical progression after a first-psychotic episode
000128077 260__ $$c2022
000128077 5060_ $$aAccess copy available to the general public$$fUnrestricted
000128077 5203_ $$aBackground
Clinical intervention in early stages of psychotic disorders is crucial for the prevention of severe symptomatology trajectories and poor outcomes. Genetic variability is studied as a promising modulator of prognosis, thus novel approaches considering the polygenic nature of these complex phenotypes are required to unravel the mechanisms underlying the early progression of the disorder.
Methods
The sample comprised of 233 first-episode psychosis (FEP) subjects with clinical and cognitive data assessed periodically for a 2-year period and 150 matched controls. Polygenic risk scores (PRSs) for schizophrenia, bipolar disorder, depression, education attainment and cognitive performance were used to assess the genetic risk of FEP and to characterize their association with premorbid, baseline and progression of clinical and cognitive status.
Results
Schizophrenia, bipolar disorder and cognitive performance PRSs were associated with an increased risk of FEP [false discovery rate (FDR) ⩽ 0.027]. In FEP patients, increased cognitive PRSs were found for FEP patients with more cognitive reserve (FDR ⩽ 0.037). PRSs reflecting a genetic liability for improved cognition were associated with a better course of symptoms, functionality and working memory (FDR ⩽ 0.039). Moreover, the PRS of depression was associated with a worse trajectory of the executive function and the general cognitive status (FDR ⩽ 0.001).
Conclusions
Our study provides novel evidence of the polygenic bases of psychosis and its clinical manifestation in its first stage. The consistent effect of cognitive PRSs on the early clinical progression suggests that the mechanisms underlying the psychotic episode and its severity could be partially independent.
000128077 536__ $$9info:eu-repo/grantAgreement/ES/ISCIII/PI08-0208$$9info:eu-repo/grantAgreement/ES/MICIU-ISCIII-FEDER/PI11-00325$$9info:eu-repo/grantAgreement/ES/MICIU-ISCIII-FEDER/PI14-00612$$9info:eu-repo/grantAgreement/ES/MICIU-ISCIII-FEDER/PI18-01055
000128077 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000128077 590__ $$a6.9$$b2022
000128077 591__ $$aPSYCHIATRY$$b27 / 154 = 0.175$$c2022$$dQ1$$eT1
000128077 591__ $$aPSYCHOLOGY, CLINICAL$$b10 / 131 = 0.076$$c2022$$dQ1$$eT1
000128077 591__ $$aPSYCHIATRY$$b21 / 143 = 0.147$$c2022$$dQ1$$eT1
000128077 591__ $$aPSYCHOLOGY$$b9 / 81 = 0.111$$c2022$$dQ1$$eT1
000128077 592__ $$a2.465$$b2022
000128077 593__ $$aPsychiatry and Mental Health$$c2022$$dQ1
000128077 593__ $$aApplied Psychology$$c2022$$dQ1
000128077 594__ $$a13.6$$b2022
000128077 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000128077 700__ $$aMezquida, Gisela
000128077 700__ $$aMartínez-Pinteño, Albert
000128077 700__ $$aGassó, Patricia
000128077 700__ $$aRodriguez, Natalia
000128077 700__ $$aMoreno-Izco, Lucía
000128077 700__ $$aAmoretti, Silvia
000128077 700__ $$aBioque, Miquel
000128077 700__ $$0(orcid)0000-0002-9098-655X$$aLobo, Antonio$$uUniversidad de Zaragoza
000128077 700__ $$aGonzález-Pinto, Ana
000128077 700__ $$aGarcía-Alcon, Alicia
000128077 700__ $$aRoldán-Bejarano, Alexandra
000128077 700__ $$aVieta, Eduard
000128077 700__ $$ade la Serna, Elena
000128077 700__ $$aToll, Alba
000128077 700__ $$aCuesta, Manuel J.
000128077 700__ $$aMas, Sergi
000128077 700__ $$aBernardo, Miquel
000128077 7102_ $$11007$$2745$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Psiquiatría
000128077 773__ $$g53, 10 (2022), 4634-4647$$pPsychol. med.$$tPsychological Medicine$$x0033-2917
000128077 8564_ $$s374891$$uhttps://zaguan.unizar.es/record/128077/files/texto_completo.pdf$$yVersión publicada
000128077 8564_ $$s2989077$$uhttps://zaguan.unizar.es/record/128077/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000128077 909CO $$ooai:zaguan.unizar.es:128077$$particulos$$pdriver
000128077 951__ $$a2024-03-18-17:07:36
000128077 980__ $$aARTICLE