000128092 001__ 128092
000128092 005__ 20241125101159.0
000128092 0247_ $$2doi$$a10.1016/j.compbiomed.2023.107381
000128092 0248_ $$2sideral$$a135251
000128092 037__ $$aART-2023-135251
000128092 041__ $$aeng
000128092 100__ $$aAsbai-Ghoudan, Reduan
000128092 245__ $$aIn silico assessment of the bone regeneration potential of complex porous scaffolds
000128092 260__ $$c2023
000128092 5060_ $$aAccess copy available to the general public$$fUnrestricted
000128092 5203_ $$aMechanical environment plays a crucial role in regulating bone regeneration in bone defects. Assessing the mechanobiological behavior of patient-specific orthopedic scaffolds in-silico could help guide optimal scaffold designs, as well as intra- and post-operative strategies to enhance bone regeneration and improve implant longevity. Additively manufactured porous scaffolds, and specifically triply periodic minimal surfaces (TPMS), have shown promising structural properties to act as bone substitutes, yet their ability to induce mechanobiologially-driven bone regeneration has not been elucidated. The aim of this study is to i) explore the bone regeneration potential of TPMS scaffolds made of different stiffness biocompatible materials, to ii) analyze the influence of pre-seeding the scaffolds and increasing the post-operative resting period, and to iii) assess the influence of patient-specific parameters, such as age and mechanosensitivity, on outcomes. To perform this study, an in silico model of a goat tibia is used. The bone ingrowth within the scaffold pores was simulated with a mechano-driven model of bone regeneration. Results showed that the scaffold's architectural properties affect cellular diffusion and strain distribution, resulting in variations in the regenerated bone volume and distribution. The softer material improved the bone ingrowth. An initial resting period improved the bone ingrowth but not enough to reach the scaffold's core. However, this was achieved with the implantation of a pre-seeded scaffold. Physiological parameters like age and health of the patient also influence the bone regeneration outcome, though to a lesser extent than the scaffold design. This analysis demonstrates the importance of the scaffold's geometry and its material, and highlights the potential of using mechanobiological patient-specific models in the design process for bone substitutes.
000128092 536__ $$9info:eu-repo/grantAgreement/ES/AEI/PID2020-113819RB-I00$$9info:eu-repo/grantAgreement/ES/AEI/PID2021-126471OA-I00
000128092 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
000128092 590__ $$a7.0$$b2023
000128092 592__ $$a1.481$$b2023
000128092 591__ $$aBIOLOGY$$b7 / 109 = 0.064$$c2023$$dQ1$$eT1
000128092 593__ $$aHealth Informatics$$c2023$$dQ1
000128092 591__ $$aMATHEMATICAL & COMPUTATIONAL BIOLOGY$$b2 / 66 = 0.03$$c2023$$dQ1$$eT1
000128092 593__ $$aComputer Science Applications$$c2023$$dQ1
000128092 591__ $$aENGINEERING, BIOMEDICAL$$b16 / 123 = 0.13$$c2023$$dQ1$$eT1
000128092 591__ $$aCOMPUTER SCIENCE, INTERDISCIPLINARY APPLICATIONS$$b19 / 170 = 0.112$$c2023$$dQ1$$eT1
000128092 594__ $$a11.7$$b2023
000128092 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000128092 700__ $$aNasello, Gabriele
000128092 700__ $$0(orcid)0000-0002-2901-4188$$aPérez, María Ángeles$$uUniversidad de Zaragoza
000128092 700__ $$aVerbruggen, Stefaan W.
000128092 700__ $$aRuiz de Galarreta, Sergio
000128092 700__ $$aRodriguez-Florez, Naiara
000128092 7102_ $$15004$$2605$$aUniversidad de Zaragoza$$bDpto. Ingeniería Mecánica$$cÁrea Mec.Med.Cont. y Teor.Est.
000128092 773__ $$g165 (2023), 107381 [12 pp.]$$pComput. biol. med.$$tComputers in biology and medicine$$x0010-4825
000128092 8564_ $$s13972682$$uhttps://zaguan.unizar.es/record/128092/files/texto_completo.pdf$$yVersión publicada
000128092 8564_ $$s2382161$$uhttps://zaguan.unizar.es/record/128092/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000128092 909CO $$ooai:zaguan.unizar.es:128092$$particulos$$pdriver
000128092 951__ $$a2024-11-22-12:10:54
000128092 980__ $$aARTICLE