000128099 001__ 128099
000128099 005__ 20231108213504.0
000128099 0247_ $$2doi$$a10.1016/j.celrep.2021.108757
000128099 0248_ $$2sideral$$a135224
000128099 037__ $$aART-2021-135224
000128099 041__ $$aeng
000128099 100__ $$0(orcid)0000-0001-5573-6144$$aLayunta, E.$$uUniversidad de Zaragoza
000128099 245__ $$aIL-22 promotes the formation of a MUC17 glycocalyx barrier in the postnatal small intestine during weaning
000128099 260__ $$c2021
000128099 5060_ $$aAccess copy available to the general public$$fUnrestricted
000128099 5203_ $$aThe intestine is under constant exposure to chemicals, antigens, and microorganisms from the external environment. Apical aspects of transporting epithelial cells (enterocytes) form a brush-border membrane (BBM), shaped by packed microvilli coated with a dense glycocalyx. We present evidence showing that the glycocalyx forms an epithelial barrier that prevents exogenous molecules and live bacteria from gaining access to BBM. We use a multi-omics approach to investigate the function and regulation of membrane mucins exposed on the BBM during postnatal development of the mouse small intestine. Muc17 is identified as a major membrane mucin in the glycocalyx that is specifically upregulated by IL-22 as part of an epithelial defense repertoire during weaning. High levels of IL-22 at time of weaning reprogram neonatal postmitotic progenitor enterocytes to differentiate into Muc17-expressing enterocytes, as found in the adult intestine during homeostasis. Our findings propose a role for Muc17 in epithelial barrier function in the small intestine.
000128099 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000128099 590__ $$a9.995$$b2021
000128099 591__ $$aCELL BIOLOGY$$b33 / 195 = 0.169$$c2021$$dQ1$$eT1
000128099 592__ $$a4.845$$b2021
000128099 593__ $$aBiochemistry, Genetics and Molecular Biology (miscellaneous)$$c2021$$dQ1
000128099 594__ $$a15.1$$b2021
000128099 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000128099 700__ $$aJäverfelt, S.
000128099 700__ $$aDolan, B.
000128099 700__ $$aArike, L.
000128099 700__ $$aPelaseyed, T.
000128099 7102_ $$11012$$2410$$aUniversidad de Zaragoza$$bDpto. Farmac.Fisiol.y Med.L.F.$$cÁrea Fisiología
000128099 773__ $$g34, 7 (2021), 108757 [24 pp.]$$pCell Reports$$tCell Reports$$x2211-1247
000128099 8564_ $$s9794696$$uhttps://zaguan.unizar.es/record/128099/files/texto_completo.pdf$$yVersión publicada
000128099 8564_ $$s1353691$$uhttps://zaguan.unizar.es/record/128099/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000128099 909CO $$ooai:zaguan.unizar.es:128099$$particulos$$pdriver
000128099 951__ $$a2023-11-08-20:04:15
000128099 980__ $$aARTICLE