000128110 001__ 128110
000128110 005__ 20240731103310.0
000128110 0247_ $$2doi$$a10.1038/s41390-022-02377-1
000128110 0248_ $$2sideral$$a130989
000128110 037__ $$aART-2023-130989
000128110 041__ $$aeng
000128110 100__ $$aSalazar Tortosa, Diego F.
000128110 245__ $$aAssociation between PTPN1 polymorphisms and obesity-related phenotypes in European adolescents: influence of physical activity
000128110 260__ $$c2023
000128110 5060_ $$aAccess copy available to the general public$$fUnrestricted
000128110 5203_ $$aBackground: To study the associations of Protein Tyrosine Phosphatase-N1 (PTPN1) polymorphisms with obesity-related phenotypes in European adolescents, and the influence of physical activity on these relationships. Methods: Five polymorphisms of PTPN1 were genotyped in 1057 European adolescents (12–18 years old). We measured several phenotypes related to obesity, such as adiposity markers, and biochemical and clinical parameters. Physical activity was objectively measured by accelerometry. Results: The T, A, T, T and G alleles of the rs6067472, rs10485614, rs2143511, rs6020608 and rs968701 polymorphisms, respectively, were associated with lower levels of obesity-related phenotypes (i.e., body mass index, body fat percentage, hip circumference, fat mass index, systolic blood pressure and leptin) in European adolescents. In addition, the TATTG haplotype was associated with lower body fat percentage and fat mass index compared to the AACCA haplotype. Finally, when physical activity levels were considered, alleles of the rs6067472, rs2143511, rs6020608 and rs968701 polymorphisms were only associated with lower adiposity in active adolescents. Conclusions: PTPN1 polymorphisms were associated with adiposity in European adolescents. Specifically, alleles of these polymorphisms were associated with lower adiposity only in physically active adolescents. Therefore, meeting the recommendations of daily physical activity may reduce obesity risk by modulating the genetic predisposition to obesity. Impact:
- Using gene-phenotype and gene*environment analyses, we detected associations between polymorphisms of the Protein Tyrosine Phosphatase-N1 (PTPN1) gene and obesity-related phenotypes, suggesting a mechanism that can be modulated by physical activity.
- This study shows that genetic variability of PTPN1 is associated with adiposity, while physical activity seems to modulate the genetic predisposition.
- This brings insights about the mechanisms by which physical activity positively influences obesity.
000128110 536__ $$9info:eu-repo/grantAgreement/EUR/FP6/FOOD-CT-2005-007034$$9info:eu-repo/grantAgreement/ES/MICINN/AGL2007-29784-E
000128110 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000128110 590__ $$a3.1$$b2023
000128110 592__ $$a1.184$$b2023
000128110 591__ $$aPEDIATRICS$$b25 / 186 = 0.134$$c2023$$dQ1$$eT1
000128110 593__ $$aPediatrics, Perinatology and Child Health$$c2023$$dQ1
000128110 594__ $$a6.8$$b2023
000128110 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/submittedVersion
000128110 700__ $$aLabayen, Idoia
000128110 700__ $$aGonzález Gross, Marcela
000128110 700__ $$0(orcid)0000-0001-6899-5938$$aSeral Cortes, Miguel$$uUniversidad de Zaragoza
000128110 700__ $$0(orcid)0000-0003-0454-653X$$aMoreno, Luis A.$$uUniversidad de Zaragoza
000128110 700__ $$aZapico, A.G.
000128110 700__ $$aWidhalm, Kurt
000128110 700__ $$aMeirhaeghe, Aline
000128110 700__ $$aEnard, David
000128110 700__ $$aRuiz, J.R.
000128110 7102_ $$11006$$2255$$aUniversidad de Zaragoza$$bDpto. Fisiatría y Enfermería$$cÁrea Enfermería
000128110 773__ $$g93 (2023), 2036–2044$$pPediatr. res.$$tPediatric research$$x0031-3998
000128110 8564_ $$s514270$$uhttps://zaguan.unizar.es/record/128110/files/texto_completo.pdf$$yPreprint
000128110 8564_ $$s945818$$uhttps://zaguan.unizar.es/record/128110/files/texto_completo.jpg?subformat=icon$$xicon$$yPreprint
000128110 909CO $$ooai:zaguan.unizar.es:128110$$particulos$$pdriver
000128110 951__ $$a2024-07-31-09:39:05
000128110 980__ $$aARTICLE