000128119 001__ 128119 000128119 005__ 20241125101124.0 000128119 0247_ $$2doi$$a10.1007/s00441-022-03688-9 000128119 0248_ $$2sideral$$a130764 000128119 037__ $$aART-2023-130764 000128119 041__ $$aeng 000128119 100__ $$0(orcid)0000-0001-9075-2764$$aOtero, Alicia$$uUniversidad de Zaragoza 000128119 245__ $$aEmergence of CWD strains 000128119 260__ $$c2023 000128119 5060_ $$aAccess copy available to the general public$$fUnrestricted 000128119 5203_ $$aChronic wasting disease (CWD) strains present a novel challenge to defining and mitigating this contagious prion disease of deer, elk, moose, and reindeer. Similar to strains of other prion diseases (bovine spongiform encephalopathy, sheep scrapie), CWD strains can affect biochemical and neuropathological properties of the infectious agent, and importantly interspecies transmission. To date, ten CWD strains have been characterized. The expanding range of CWD in North America and its presence in South Korea as well as Scandinavian countries will potentially result in millions of cervids infected with CWD; thus, novel strains will continue to emerge. In this review, we will summarize the characteristics of known CWD strains and describe the impact of prion protein gene polymorphisms on the generation of strains. We will also discuss the evidence that individual cervids can harbor more than one CWD strain, complicating strain analysis, and affecting selection and adaptation of strains in new hosts. 000128119 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/ 000128119 590__ $$a3.2$$b2023 000128119 592__ $$a0.965$$b2023 000128119 591__ $$aCELL BIOLOGY$$b123 / 205 = 0.6$$c2023$$dQ3$$eT2 000128119 593__ $$aHistology$$c2023$$dQ1 000128119 593__ $$aPathology and Forensic Medicine$$c2023$$dQ1 000128119 593__ $$aCell Biology$$c2023$$dQ2 000128119 594__ $$a7.0$$b2023 000128119 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion 000128119 700__ $$aDuque Velasquez, Camilo 000128119 700__ $$aMcKenzie, Debbie 000128119 700__ $$aAiken, Judd 000128119 7102_ $$11009$$2773$$aUniversidad de Zaragoza$$bDpto. Patología Animal$$cÁrea Sanidad Animal 000128119 773__ $$g392 (2023), 135–148$$pCell tissue res.$$tCELL AND TISSUE RESEARCH$$x0302-766X 000128119 8564_ $$s997170$$uhttps://zaguan.unizar.es/record/128119/files/texto_completo.pdf$$yVersión publicada 000128119 8564_ $$s2454516$$uhttps://zaguan.unizar.es/record/128119/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada 000128119 909CO $$ooai:zaguan.unizar.es:128119$$particulos$$pdriver 000128119 951__ $$a2024-11-22-11:57:22 000128119 980__ $$aARTICLE