128119 20241125101124.0 doi 10.1007/s00441-022-03688-9 sideral 130764 ART-2023-130764 eng Otero, Alicia Universidad de Zaragoza (orcid)0000-0001-9075-2764 Emergence of CWD strains 2023 Access copy available to the general public Unrestricted Chronic wasting disease (CWD) strains present a novel challenge to defining and mitigating this contagious prion disease of deer, elk, moose, and reindeer. Similar to strains of other prion diseases (bovine spongiform encephalopathy, sheep scrapie), CWD strains can affect biochemical and neuropathological properties of the infectious agent, and importantly interspecies transmission. To date, ten CWD strains have been characterized. The expanding range of CWD in North America and its presence in South Korea as well as Scandinavian countries will potentially result in millions of cervids infected with CWD; thus, novel strains will continue to emerge. In this review, we will summarize the characteristics of known CWD strains and describe the impact of prion protein gene polymorphisms on the generation of strains. We will also discuss the evidence that individual cervids can harbor more than one CWD strain, complicating strain analysis, and affecting selection and adaptation of strains in new hosts. info:eu-repo/semantics/openAccess All rights reserved http://www.europeana.eu/rights/rr-f/ 3.2 2023 CELL BIOLOGY 123 / 205 = 0.6 2023 Q3 T2 0.965 2023 Histology 2023 Q1 Pathology and Forensic Medicine 2023 Q1 Cell Biology 2023 Q2 7.0 2023 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Duque Velasquez, Camilo McKenzie, Debbie Aiken, Judd 1009 773 Universidad de Zaragoza Dpto. Patología Animal Área Sanidad Animal 392 (2023), 135–148 Cell tissue res. CELL AND TISSUE RESEARCH 0302-766X 997170 http://zaguan.unizar.es/record/128119/files/texto_completo.pdf Versión publicada 2454516 http://zaguan.unizar.es/record/128119/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:128119 articulos driver 2024-11-22-11:57:22 ARTICLE