000128137 001__ 128137
000128137 005__ 20240705134158.0
000128137 0247_ $$2doi$$a10.1021/acsami.3c04245
000128137 0248_ $$2sideral$$a135305
000128137 037__ $$aART-2023-135305
000128137 041__ $$aeng
000128137 100__ $$aPerez-Estenaga, Iñigo
000128137 245__ $$aA Multimodal Scaffold for SDF1 Delivery Improves Cardiac Function in a Rat Subacute Myocardial Infarct Model
000128137 260__ $$c2023
000128137 5060_ $$aAccess copy available to the general public$$fUnrestricted
000128137 5203_ $$aIschemic heart disease is one of the leading causes of death worldwide. The efficient delivery of therapeutic growth factors could counteract the adverse prognosis of post-myocardial infarction (post-MI). In this study, a collagen hydrogel that is able to load and appropriately deliver pro-angiogenic stromal cell-derived factor 1 (SDF1) was physically coupled with a compact collagen membrane in order to provide the suture strength required for surgical implantation. This bilayer collagen-on-collagen scaffold (bCS) showed the suitable physicochemical properties that are needed for efficient implantation, and the scaffold was able to deliver therapeutic growth factors after MI. In vitro collagen matrix biodegradation led to a sustained SDF1 release and a lack of cytotoxicity in the relevant cell cultures. In vivo intervention in a rat subacute MI model resulted in the full integration of the scaffold into the heart after implantation and biocompatibility with the tissue, with a prevalence of anti-inflammatory and pro-angiogenic macrophages, as well as evidence of revascularization and improved cardiac function after 60 days. Moreover, the beneficial effect of the released SDF1 on heart remodeling was confirmed by a significant reduction in cardiac tissue stiffness. Our findings demonstrate that this multimodal scaffold is a desirable matrix that can be used as a drug delivery system and a scaffolding material to promote functional recovery after MI.
000128137 536__ $$9info:eu-repo/grantAgreement/EC/H2020/713690/EU/Career Development and Mobility Fellowships in Medical Device Research and Development: A CÚRAM Industry-Academia Training Initiative/MedTrain$$9This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 713690-MedTrain$$9info:eu-repo/grantAgreement/ES/ISCIII/AC15-00050$$9info:eu-repo/grantAgreement/ES/ISCIII/FEDER/RD16-0011-0005$$9info:eu-repo/grantAgreement/ES/ISCIII/PI19-00501$$9info:eu-repo/grantAgreement/ES/MICIU/RTC-2016-4911-1$$9info:eu-repo/grantAgreement/EUR/SUDOE/INTERREG CARDIOPATCH-SOE4-P1-E1063
000128137 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000128137 592__ $$a2.058$$b2023
000128137 593__ $$aMaterials Science (miscellaneous)$$c2023$$dQ1
000128137 593__ $$aNanoscience and Nanotechnology$$c2023$$dQ1
000128137 593__ $$aMedicine (miscellaneous)$$c2023$$dQ1
000128137 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000128137 700__ $$aChevalier, Merari Tumin
000128137 700__ $$0(orcid)0000-0002-0664-5024$$aPeña, Estefania$$uUniversidad de Zaragoza
000128137 700__ $$aAbizanda, Gloria
000128137 700__ $$aAlsharabasy, Amir M.
000128137 700__ $$aLarequi, Eduardo
000128137 700__ $$0(orcid)0000-0002-8503-9291$$aCilla, Myriam$$uUniversidad de Zaragoza
000128137 700__ $$0(orcid)0000-0002-8133-2124$$aPerez, Marta M.$$uUniversidad de Zaragoza
000128137 700__ $$aGurtubay, Jon
000128137 700__ $$aGarcia-Yebenes Castro, Manuel
000128137 700__ $$aProsper, Felipe
000128137 700__ $$aPandit, Abhay
000128137 700__ $$aPelacho, Beatriz
000128137 7102_ $$11001$$2025$$aUniversidad de Zaragoza$$bDpto. Anatom.,Embri.Genét.Ani.$$cÁrea Anatom.Anatom.Patológ.Com
000128137 7102_ $$15004$$2605$$aUniversidad de Zaragoza$$bDpto. Ingeniería Mecánica$$cÁrea Mec.Med.Cont. y Teor.Est.
000128137 773__ $$g15, 44 (2023), 50638-50651$$pACS appl. mater. interfaces$$tACS applied materials & interfaces$$x1944-8244
000128137 8564_ $$s11560437$$uhttps://zaguan.unizar.es/record/128137/files/texto_completo.pdf$$yVersión publicada
000128137 8564_ $$s3357860$$uhttps://zaguan.unizar.es/record/128137/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000128137 909CO $$ooai:zaguan.unizar.es:128137$$particulos$$pdriver
000128137 951__ $$a2024-07-05-12:50:28
000128137 980__ $$aARTICLE