000128212 001__ 128212
000128212 005__ 20241125101201.0
000128212 0247_ $$2doi$$a10.1038/s41467-023-41768-8
000128212 0248_ $$2sideral$$a135427
000128212 037__ $$aART-2023-135427
000128212 041__ $$aeng
000128212 100__ $$0(orcid)0000-0002-0182-201X$$aMoreo, Eduardo$$uUniversidad de Zaragoza
000128212 245__ $$aIntravenous administration of BCG in mice promotes natural killer and T cell-mediated antitumor immunity in the lung
000128212 260__ $$c2023
000128212 5060_ $$aAccess copy available to the general public$$fUnrestricted
000128212 5203_ $$aIntravesical administration of Bacillus Calmette-Guérin (BCG) was one of the first FDA-approved immunotherapies and remains a standard treatment for bladder cancer. Previous studies have demonstrated that intravenous (IV) administration of BCG is well-tolerated and effective in preventing tuberculosis infection in animals. Here, we examine IV BCG in several preclinical lung tumor models. Our findings demonstrate that BCG inoculation reduced tumor growth and prolonged mouse survival in models of lung melanoma metastasis and orthotopic lung adenocarcinoma. Moreover, IV BCG treatment was well-tolerated with no apparent signs of acute toxicity. Mechanistically, IV BCG induced tumor-specific CD8+ T cell responses, which were dependent on type 1 conventional dendritic cells, as well as NK cell-mediated immunity. Lastly, we also show that IV BCG has an additive effect on anti-PD-L1 checkpoint inhibitor treatment in mouse lung tumors that are otherwise resistant to anti-PD-L1 as monotherapy. Overall, our study demonstrates the potential of systemic IV BCG administration in the treatment of lung tumors, highlighting its ability to enhance immune responses and augment immune checkpoint blockade efficacy.
000128212 536__ $$9info:eu-repo/grantAgreement/ES/DGA/LMP50-21$$9info:eu-repo/grantAgreement/EC/H2020/725091/EU/Functional characterisation of mitochondrial metabolic adaptations to innate sensing in dendritic cell subsets/MITOMAD$$9This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 725091-MITOMAD$$9info:eu-repo/grantAgreement/ES/ISCIII/CB21-13-100087$$9info:eu-repo/grantAgreement/ES/ISCIII/CP20-00106$$9info:eu-repo/grantAgreement/EUR/MCIN/AEI/CPP2021-008310$$9info:eu-repo/grantAgreement/ES/MCINN/PID2021-123795OB-I00$$9info:eu-repo/grantAgreement/ES/MICINN/PID2019-108157RB$$9info:eu-repo/grantAgreement/ES/MICINN/RTI2018-097625-B-100
000128212 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000128212 590__ $$a14.7$$b2023
000128212 592__ $$a4.887$$b2023
000128212 591__ $$aMULTIDISCIPLINARY SCIENCES$$b8 / 134 = 0.06$$c2023$$dQ1$$eT1
000128212 593__ $$aBiochemistry, Genetics and Molecular Biology (miscellaneous)$$c2023$$dQ1
000128212 593__ $$aPhysics and Astronomy (miscellaneous)$$c2023$$dQ1
000128212 593__ $$aChemistry (miscellaneous)$$c2023$$dQ1
000128212 594__ $$a24.9$$b2023
000128212 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000128212 700__ $$aJarit-Cabanillas, Aitor
000128212 700__ $$aRobles-Vera, Iñaki
000128212 700__ $$0(orcid)0000-0001-7866-2803$$aUranga, Santiago$$uUniversidad de Zaragoza
000128212 700__ $$0(orcid)0000-0002-7963-7797$$aGuerrero, Claudia$$uUniversidad de Zaragoza
000128212 700__ $$0(orcid)0000-0002-9713-2127$$aGómez, Ana Belén$$uUniversidad de Zaragoza
000128212 700__ $$aMata-Martínez, Pablo
000128212 700__ $$aMinute, Luna
000128212 700__ $$aAraujo-Voces, Miguel
000128212 700__ $$aFelgueres, María José
000128212 700__ $$aEsteso, Gloria
000128212 700__ $$aUranga-Murillo, Iratxe
000128212 700__ $$aArias, Maykel
000128212 700__ $$0(orcid)0000-0003-0154-0730$$aPardo, Julián$$uUniversidad de Zaragoza
000128212 700__ $$0(orcid)0000-0003-2993-5478$$aMartín, Carlos$$uUniversidad de Zaragoza
000128212 700__ $$aValés-Gómez, Mar
000128212 700__ $$adel Fresno, Carlos
000128212 700__ $$aSancho, David
000128212 700__ $$0(orcid)0000-0001-7897-9173$$aAguiló, Nacho$$uUniversidad de Zaragoza
000128212 7102_ $$11011$$2630$$aUniversidad de Zaragoza$$bDpto. Microb.Ped.Radio.Sal.Pú.$$cÁrea Microbiología
000128212 7102_ $$11011$$2566$$aUniversidad de Zaragoza$$bDpto. Microb.Ped.Radio.Sal.Pú.$$cÁrea Inmunología
000128212 7102_ $$11011$$2X$$aUniversidad de Zaragoza$$bDpto. Microb.Ped.Radio.Sal.Pú.$$cProy. investigación HQA
000128212 773__ $$g14, 1 (2023), 690[ 17 pp]$$tNature communications$$x2041-1723
000128212 8564_ $$s5108133$$uhttps://zaguan.unizar.es/record/128212/files/texto_completo.pdf$$yVersión publicada
000128212 8564_ $$s2399273$$uhttps://zaguan.unizar.es/record/128212/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000128212 909CO $$ooai:zaguan.unizar.es:128212$$particulos$$pdriver
000128212 951__ $$a2024-11-22-12:11:42
000128212 980__ $$aARTICLE