A case of canine intestinal malakoplakia

Gómez, Álex (Universidad de Zaragoza) ; Pérez, Estela (Universidad de Zaragoza) ; Calvo-Sánchez, Natalia (Universidad de Zaragoza) ; Pérez, Marta (Universidad de Zaragoza) ; Borobia, María ; Luján, Lluís (Universidad de Zaragoza) ; Rodríguez-Largo, Ana (Universidad de Zaragoza) ; Villanueva-Saz, Sergio (Universidad de Zaragoza)

Resumen: Malakoplakia is a rare chronic granulomatous disease usually affecting the urinary bladder and other locations. In humans, the gastrointestinal tract is the second most common location but there are no reports of intestinal malakoplakia in animals. A 10-month-old female French Bulldog was presented with chronic haemorrhagic diarrhoea and anorexia with normochromic-normocytic anaemia and hypoalbuminaemia. Grossly, there was mucosal thickening and ulceration of the caecum, colon and rectum. Microscopically, transmural sheets of foamy macrophages were seen in these tissues. Macrophages were periodic acid–Schiff, vimentin and ionized calcium-binding adaptor molecule 1 positive and contained von Kossa- and Prussian blue-positive Michaelis–Gutmann bodies. Giemsa staining revealed rod-shaped bacterial colonies and fluorescence in-situ hybridization demonstrated Escherichia coli within macrophages. This is the first reported case of intestinal malakoplakia in domestic animals. Pathological features of intestinal malakoplakia share many similarities with ulcerative histiocytic colitis in dogs but it is unclear if they are different forms of the same pathological process or distinct entities.

Idioma: Inglés

DOI: 10.1016/j.jcpa.2023.07.002

Año: 2023

Publicado en: JOURNAL OF COMPARATIVE PATHOLOGY 205 (2023), 33-37
ISSN: 0021-9975

Factor impacto JCR: 0.8 (2023)

Categ. JCR: VETERINARY SCIENCES rank: 108 / 167 = 0.647 (2023) - Q3 - T2
Categ. JCR: PATHOLOGY rank: 75 / 88 = 0.852 (2023) - Q4 - T3

Factor impacto CITESCORE: 1.6 - Veterinary (all) (Q2) - Pathology and Forensic Medicine (Q3)

Factor impacto SCIMAGO: 0.376 - Veterinary (miscellaneous) (Q2) - Pathology and Forensic Medicine (Q3)

Tipo y forma: Artículo (Versión definitiva)

Área (Departamento): Área Sanidad Animal (Dpto. Patología Animal)
Área (Departamento): Área Anatom.Anatom.Patológ.Com (Dpto. Anatom.,Embri.Genét.Ani.)
Área (Departamento): Área Medicina y Cirugía Animal (Dpto. Patología Animal)