000128216 001__ 128216
000128216 005__ 20231129155502.0
000128216 0247_ $$2doi$$a10.1016/j.jcpa.2023.07.003
000128216 0248_ $$2sideral$$a135528
000128216 037__ $$aART-2023-135528
000128216 041__ $$aeng
000128216 100__ $$aGómez, Álex$$uUniversidad de Zaragoza
000128216 245__ $$aFeline osteochondromatosis in a 12-year-old feline leukaemia virus-negative cat
000128216 260__ $$c2023
000128216 5060_ $$aAccess copy available to the general public$$fUnrestricted
000128216 5203_ $$aFeline osteochondromatosis is a spontaneous osteocartilaginous exostosis associated with feline leukaemia virus (FeLV) infection or due to a frameshift variant in the exostosin glycosyltransferase 1 (EXT1) gene. Osteochondromatosis was diagnosed in an indoor-only, 12-year-old, neutered female, Russian Blue cat. Radiographs revealed bilateral calcified proliferations in the elbow, costochondral and sternochondral joints, which distorted the normal skeletal structure. Grossly, the proliferated joints presented with consistent, rounded masses, causing complete ankylosis. The main histopathological finding was an osteocartilaginous proliferation composed of multiple irregular islands of well-differentiated hyaline cartilage surrounded and delimited by osteoid tissue. Immunohistochemistry of the osteochondromas, bone marrow and mediastinal lymph nodes, using a primary anti-FeLV gp70 antibody, and FeLV proviral DNA real-time polymerase chain reaction on bone marrow were negative. Sequencing of exon 6 of the EXT1 gene was performed and nucleotide BLAST analysis demonstrated the absence of a frameshift variant. This study reports the only case of spontaneous feline osteochondromatosis in an animal more than 10 years old.
000128216 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
000128216 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000128216 700__ $$0(orcid)0000-0002-2685-1730$$aRodríguez-Largo, Ana$$uUniversidad de Zaragoza
000128216 700__ $$aPérez, Estela$$uUniversidad de Zaragoza
000128216 700__ $$aCalvo-Sánchez, Natalia$$uUniversidad de Zaragoza
000128216 700__ $$aLoomans, Sarah
000128216 700__ $$aChiers, Koen
000128216 700__ $$0(orcid)0000-0003-0210-2919$$aMonteagudo, Luis$$uUniversidad de Zaragoza
000128216 700__ $$0(orcid)0000-0002-2053-9842$$aLuján, Lluís$$uUniversidad de Zaragoza
000128216 700__ $$0(orcid)0000-0002-8133-2124$$aPérez, Marta$$uUniversidad de Zaragoza
000128216 7102_ $$11001$$2420$$aUniversidad de Zaragoza$$bDpto. Anatom.,Embri.Genét.Ani.$$cÁrea Genética
000128216 7102_ $$11009$$2773$$aUniversidad de Zaragoza$$bDpto. Patología Animal$$cÁrea Sanidad Animal
000128216 7102_ $$11001$$2025$$aUniversidad de Zaragoza$$bDpto. Anatom.,Embri.Genét.Ani.$$cÁrea Anatom.Anatom.Patológ.Com
000128216 773__ $$g205 (2023), 24-26$$pJ. Comp. Pathol.$$tJOURNAL OF COMPARATIVE PATHOLOGY$$x0021-9975
000128216 8564_ $$s1113423$$uhttps://zaguan.unizar.es/record/128216/files/texto_completo.pdf$$yVersión publicada
000128216 8564_ $$s2810106$$uhttps://zaguan.unizar.es/record/128216/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000128216 909CO $$ooai:zaguan.unizar.es:128216$$particulos$$pdriver
000128216 951__ $$a2023-11-29-15:04:34
000128216 980__ $$aARTICLE