000128218 001__ 128218
000128218 005__ 20241125101146.0
000128218 0247_ $$2doi$$a10.3390/biomedicines11112972
000128218 0248_ $$2sideral$$a135476
000128218 037__ $$aART-2023-135476
000128218 041__ $$aeng
000128218 100__ $$aBoned-Murillo, Ana
000128218 245__ $$aChanges in inner retina thickness and macular sensitivity in patients with type 2 diabetes with moderate diabetic retinopathy
000128218 260__ $$c2023
000128218 5060_ $$aAccess copy available to the general public$$fUnrestricted
000128218 5203_ $$aThe increase in diabetic retinopathy (DR) prevalence demonstrates the need for the determination of biomarkers for assessing disease development to obtain an early diagnosis and stop its progression. We aimed to analyse total retinal (RT) and inner retinal layer (IRL) thicknesses in type 2 diabetes mellitus (DM2) patients and correlate these results with retinal sensitivity using swept-source OCT (SS-OCT) and microperimetry. For this purpose, a total of 54 DM2 subjects with moderate diabetic retinopathy (DR) with no signs of diabetic macular oedema (DME) and 73 age-matched healthy individuals were assessed using SS-OCT to quantify retinal thickness in the nine macular areas of the ETDRS grid. Retinal sensitivity was measured via microperimetry with a Macular Integrity Assessment Device (MAIA). The mean ages were 64.06 ± 11.98 years for the DM2 group and 60.79 ± 8.62 years for the control group. DM2 patients presented lower visual acuity (p < 0.001) and a thicker RT (260.70 ± 19.22 μm in the control group vs. 271.90 ± 37.61 μm in the DM2 group, p = 0.01). The retinal nerve fibre layer (RNFL) was significantly lower in the outer nasal area (50.38 ± 8.20 μm vs. 45.17 ± 11.25 μm, p = 0.005) in ganglion cells and inner plexiform layers (GCL+) in DM2. A positive correlation between the LDL-C and RNFL and a negative correlation between HDL-C levels and the inner temporal and central RNFL thickness were detected. The central (p = 0.021) and inner nasal (p = 0.01) areas were negatively correlated between the RNFL and MAIA, while GCL++ was positively correlated with the outer inferior (p = 0.015) and outer nasal areas (p = 0.024). Retinal sensitivity and macular RNFL thickness decrease in DM2 patients with moderate DR with no DME, and this study enables an accurate approach to this disease with personalised assessment based on the DR course or stage. Thus, GCL+ and GCL++ thinning may support ganglion cell loss before the RNFL is affected.
000128218 536__ $$9info:eu-repo/grantAgreement/ES/DGA/B08-20R$$9info:eu-repo/grantAgreement/ES/ISCIII-FEDER/PI20-00740
000128218 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000128218 590__ $$a3.9$$b2023
000128218 592__ $$a0.962$$b2023
000128218 591__ $$aPHARMACOLOGY & PHARMACY$$b85 / 354 = 0.24$$c2023$$dQ1$$eT1
000128218 593__ $$aMedicine (miscellaneous)$$c2023$$dQ1
000128218 591__ $$aBIOCHEMISTRY & MOLECULAR BIOLOGY$$b106 / 313 = 0.339$$c2023$$dQ2$$eT2
000128218 593__ $$aBiochemistry, Genetics and Molecular Biology (miscellaneous)$$c2023$$dQ1
000128218 591__ $$aMEDICINE, RESEARCH & EXPERIMENTAL$$b65 / 189 = 0.344$$c2023$$dQ2$$eT2
000128218 594__ $$a5.2$$b2023
000128218 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000128218 700__ $$0(orcid)0000-0003-1234-9712$$aFernández-Espinosa, Guisela
000128218 700__ $$0(orcid)0000-0003-2710-1875$$aOrduna-Hospital, Elvira$$uUniversidad de Zaragoza
000128218 700__ $$aDíaz-Barreda, Maria Dolores
000128218 700__ $$0(orcid)0000-0002-5621-1937$$aSánchez-Cano, Ana$$uUniversidad de Zaragoza
000128218 700__ $$aSopeña-Pinilla, María
000128218 700__ $$aBielsa-Alonso, Sofía
000128218 700__ $$0(orcid)0000-0003-0349-9997$$aPinilla, Isabel$$uUniversidad de Zaragoza
000128218 7102_ $$11013$$2646$$aUniversidad de Zaragoza$$bDpto. Cirugía$$cÁrea Oftalmología
000128218 7102_ $$12002$$2647$$aUniversidad de Zaragoza$$bDpto. Física Aplicada$$cÁrea Óptica
000128218 773__ $$g11, 11 (2023), 2972 [13 pp.]$$tBiomedicines$$x2227-9059
000128218 8564_ $$s1782238$$uhttps://zaguan.unizar.es/record/128218/files/texto_completo.pdf$$yVersión publicada
000128218 8564_ $$s2729179$$uhttps://zaguan.unizar.es/record/128218/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000128218 909CO $$ooai:zaguan.unizar.es:128218$$particulos$$pdriver
000128218 951__ $$a2024-11-22-12:04:25
000128218 980__ $$aARTICLE