000128226 001__ 128226
000128226 005__ 20231129155502.0
000128226 0247_ $$2doi$$a10.1016/j.jgar.2023.07.009
000128226 0248_ $$2sideral$$a135560
000128226 037__ $$aART-2023-135560
000128226 041__ $$aeng
000128226 100__ $$aHayer, Juliette
000128226 245__ $$aMultiple clonal transmissions of clinically relevant extended-spectrum beta-lactamase–producing Escherichia coli among livestock, dogs, and wildlife in Chile
000128226 260__ $$c2023
000128226 5060_ $$aAccess copy available to the general public$$fUnrestricted
000128226 5203_ $$aObjectives: Extended-spectrum beta-lactamase-producing Escherichia coli (ESBL-E. coli) are a main cause of human deaths associated with antimicrobial resistance (AMR). Despite hundreds of reports of the faecal carriage of ESBL-E. coli in domestic and wild animals, the dynamics of its circulation remains poorly understood. Methods: We used whole genome sequencing of 19 ESBL-E. coli previously isolated in the same local setting from dogs, livestock, and a wild rodent in Central Chile to assess potential cross-species transmission of ESBL-E. coli. Results: Isolates harboured a large number of AMR (n = 95) and virulence (n = 45) genes, plasmids replicons (n = 24), and E. coli sequence types including top extraintestinal pathogenic E. coli ST410, ST58, ST88, and ST617. Almost identical clones (<50 single nucleotide polymorphisms difference, same antibiotic and heavy metal resistance genes, virulence genes, and plasmids) were found in faeces of dogs, cattle, or sheep from the same farm, and in a dog and a wild rodent living in proximity. Conclusions: To our knowledge, this is the first report of multiple clonal cross-species transmission of ESBL-E. coli in domestic and potentially wild animals of Latin America. Our results suggest that relatively rare spread of AMR across animal species can still occur by both clonal and plasmid dissemination. Our study highlights the need for establishing preventive measures to limit the circulation of these bacteria among animals in agricultural settings, particularly given the highly pathogenic profile of several E. coli strains detected in these animals.
000128226 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000128226 655_4 $$ainfo:eu-repo/semantics/conferenceObject$$vinfo:eu-repo/semantics/publishedVersion
000128226 700__ $$aSalgado-Caxito, Marília
000128226 700__ $$aOpazo-Capurro, Andrés
000128226 700__ $$aGonzález Muñoz, Paulina
000128226 700__ $$0(orcid)0000-0001-5608-781X$$aMillán, Javier
000128226 700__ $$aPiñeiro, Ana
000128226 700__ $$aMunita, Jose M.
000128226 700__ $$aRivas, Lina
000128226 700__ $$aBenavides, Julio A.
000128226 773__ $$g34 (2023), 247-252$$pJ. glob. antimicrob. resistance$$tJournal of global antimicrobial resistance$$x2213-7165
000128226 8564_ $$s1845413$$uhttps://zaguan.unizar.es/record/128226/files/texto_completo.pdf$$yVersión publicada
000128226 8564_ $$s2347307$$uhttps://zaguan.unizar.es/record/128226/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000128226 909CO $$ooai:zaguan.unizar.es:128226$$particulos$$pdriver
000128226 951__ $$a2023-11-29-15:04:46
000128226 980__ $$aARTICLE