000129346 001__ 129346
000129346 005__ 20240319081010.0
000129346 0247_ $$2doi$$a10.1016/j.cma.2022.115477
000129346 0248_ $$2sideral$$a130091
000129346 037__ $$aART-2022-130091
000129346 041__ $$aeng
000129346 100__ $$0(orcid)0000-0003-4617-8130$$aAparicio-Yuste, R.$$uUniversidad de Zaragoza
000129346 245__ $$aComputational modelling of epithelial cell monolayers during infection with Listeria monocytogenes
000129346 260__ $$c2022
000129346 5060_ $$aAccess copy available to the general public$$fUnrestricted
000129346 5203_ $$aIntracellular bacterial infections alter the normal functionality of human host cells and tissues. Infection can also modify the mechanical properties of host cells, altering the mechanical equilibrium of tissues. In order to advance our understanding of host–pathogen interactions, simplified in vitro models are normally used. However, in vitro studies present certain limitations that can be alleviated by the use of computer-based models. As complementary tools these computational models, in conjunction with in vitro experiments, can enhance our understanding of the mechanisms of action underlying infection processes. In this work, we extend our previous computer-based model to simulate infection of epithelial cells with the intracellular bacterial pathogen Listeria monocytogenes. We found that forces generated by host cells play a regulatory role in the mechanobiological response to infection. After infection, in silico cells alter their mechanical properties in order to achieve a new mechanical equilibrium. The model pointed the key role of cell–cell and cell–extracellular matrix interactions in the mechanical competition of bacterial infection. The obtained results provide a more detailed description of cell and tissue responses to infection, and could help inform future studies focused on controlling bacterial dissemination and the outcome of infection processes. © 2022 The Author(s)
000129346 536__ $$9info:eu-repo/grantAgreement/ES/MCIU/FPU20-05274$$9info:eu-repo/grantAgreement/ES/MICINN/PID2021-124271OB-I00
000129346 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
000129346 590__ $$a7.2$$b2022
000129346 591__ $$aMECHANICS$$b6 / 137 = 0.044$$c2022$$dQ1$$eT1
000129346 591__ $$aMATHEMATICS, INTERDISCIPLINARY APPLICATIONS$$b4 / 107 = 0.037$$c2022$$dQ1$$eT1
000129346 591__ $$aENGINEERING, MULTIDISCIPLINARY$$b7 / 90 = 0.078$$c2022$$dQ1$$eT1
000129346 592__ $$a2.218$$b2022
000129346 593__ $$aComputational Mechanics$$c2022$$dQ1
000129346 593__ $$aComputer Science Applications$$c2022$$dQ1
000129346 593__ $$aPhysics and Astronomy (miscellaneous)$$c2022$$dQ1
000129346 593__ $$aMechanics of Materials$$c2022$$dQ1
000129346 593__ $$aMechanical Engineering$$c2022$$dQ1
000129346 594__ $$a11.6$$b2022
000129346 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000129346 700__ $$aSerrano-Alcalde, F.
000129346 700__ $$aMuenkel, M.
000129346 700__ $$0(orcid)0000-0002-9864-7683$$aGarcia-Aznar, J.$$uUniversidad de Zaragoza
000129346 700__ $$aBastounis, E. E.
000129346 700__ $$0(orcid)0000-0002-1878-8997$$aGomez-Benito, M.$$uUniversidad de Zaragoza
000129346 7102_ $$15004$$2605$$aUniversidad de Zaragoza$$bDpto. Ingeniería Mecánica$$cÁrea Mec.Med.Cont. y Teor.Est.
000129346 773__ $$g401, Part A (2022), 115477 [20 pp]$$pComput. methods appl. mech. eng.$$tComputer Methods in Applied Mechanics and Engineering$$x0045-7825
000129346 8564_ $$s3876759$$uhttps://zaguan.unizar.es/record/129346/files/texto_completo.pdf$$yPostprint
000129346 8564_ $$s561100$$uhttps://zaguan.unizar.es/record/129346/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
000129346 909CO $$ooai:zaguan.unizar.es:129346$$particulos$$pdriver
000129346 951__ $$a2024-03-18-15:04:30
000129346 980__ $$aARTICLE