000129353 001__ 129353 000129353 005__ 20241125101134.0 000129353 0247_ $$2doi$$a10.1016/j.envpol.2022.120851 000129353 0248_ $$2sideral$$a132846 000129353 037__ $$aART-2023-132846 000129353 041__ $$aeng 000129353 100__ $$aGrau-Perez, M. 000129353 245__ $$aAssociation of single and joint metals with albuminuria and estimated glomerular filtration longitudinal change in middle-aged adults from Spain: The Aragon workers health study 000129353 260__ $$c2023 000129353 5060_ $$aAccess copy available to the general public$$fUnrestricted 000129353 5203_ $$aThe nephrotoxicity of low-chronic metal exposures is unclear, especially considering several metals simultaneously. We assessed the individual and joint association of metals with longitudinal change in renal endpoints in Aragon Workers Health Study participants with available measures of essential (cobalt [Co], copper [Cu], molybdenum [Mo] and zinc [Zn]) and non-essential (As, barium [Ba], Cd, chromium [Cr], antimony [Sb], titanium [Ti], uranium [U], vanadium [V] and tungsten [W]) urine metals and albumin-to-creatinine ratio (ACR) (N = 707) and estimated glomerular filtration rate (eGFR) (N = 1493) change. Median levels were 0.24, 7.0, 18.6, 295, 3.1, 1.9, 0.28, 1.16, 9.7, 0.66, 0.22 μg/g for Co, Cu, Mo, Zn, As, Ba, Cd, Cr, Sb, Ti, V and W, respectively, and 52.5 and 27.2 ng/g for Sb and U, respectively. In single metal analysis, higher As, Cr and W concentrations were associated with increasing ACR annual change. Higher Zn, As and Cr concentrations were associated with decreasing eGFR annual change. The shape of the longitudinal dose-responses, however, was compatible with a nephrotoxic role for all metals, both in ACR and eGFR models. In joint metal analysis, both higher mixtures of Cu–Zn–As–Ba–Ti–U–V–W and Co–Cd–Cr–Sb–V–W showed associations with increasing ACR and decreasing eGFR annual change. As and Cr were main drivers of the ACR change joint metal association. For the eGFR change joint metal association, while Zn and Cr were main drivers, other metals also contributed substantially. We identified potential interactions for As, Zn and W by other metals with ACR change, but not with eGFR change. Our findings support that Zn, As, Cr and W and suggestively other metals, are nephrotoxic at relatively low exposure levels. Metal exposure reduction and mitigation interventions may improve prevention and decrease the burden of renal disease in the population. 000129353 536__ $$9info:eu-repo/grantAgreement/ES/AEI/PID2019-108973RB-C21$$9info:eu-repo/grantAgreement/ES/ISCIII/PI15-00071 000129353 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/ 000129353 590__ $$a7.6$$b2023 000129353 592__ $$a2.132$$b2023 000129353 591__ $$aENVIRONMENTAL SCIENCES$$b37 / 358 = 0.103$$c2023$$dQ1$$eT1 000129353 593__ $$aHealth, Toxicology and Mutagenesis$$c2023$$dQ1 000129353 593__ $$aToxicology$$c2023$$dQ1 000129353 593__ $$aPollution$$c2023$$dQ1 000129353 593__ $$aMedicine (miscellaneous)$$c2023$$dQ1 000129353 594__ $$a16.0$$b2023 000129353 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion 000129353 700__ $$aDomingo-Relloso, A. 000129353 700__ $$aGarcía-Barrera, T. 000129353 700__ $$aGómez-Ariza, J. L. 000129353 700__ $$aLeón-Latre, Montserrat$$uUniversidad de Zaragoza 000129353 700__ $$0(orcid)0000-0002-9887-2629$$aCasasnovas, J. A.$$uUniversidad de Zaragoza 000129353 700__ $$0(orcid)0000-0003-0604-5042$$aMoreno-Franco, B.$$uUniversidad de Zaragoza 000129353 700__ $$0(orcid)0000-0003-3963-0846$$aLaclaustra, M.$$uUniversidad de Zaragoza 000129353 700__ $$aGuallar, E. 000129353 700__ $$aNavas-Acien, A. 000129353 700__ $$aPastor-Barriuso, R. 000129353 700__ $$aRedon, J. 000129353 700__ $$aTellez-Plaza, M. 000129353 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina 000129353 7102_ $$11011$$2615$$aUniversidad de Zaragoza$$bDpto. Microb.Ped.Radio.Sal.Pú.$$cÁrea Medic.Prevent.Salud Públ. 000129353 773__ $$g318 (2023), 120851 [11 pp.]$$pEnviron. pollut.$$tEnvironmental Pollution$$x0269-7491 000129353 8564_ $$s654700$$uhttps://zaguan.unizar.es/record/129353/files/texto_completo.pdf$$yPostprint 000129353 8564_ $$s1428905$$uhttps://zaguan.unizar.es/record/129353/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint 000129353 909CO $$ooai:zaguan.unizar.es:129353$$particulos$$pdriver 000129353 951__ $$a2024-11-22-12:00:06 000129353 980__ $$aARTICLE