129353 20241125101134.0 doi 10.1016/j.envpol.2022.120851 sideral 132846 ART-2023-132846 eng Grau-Perez, M. Association of single and joint metals with albuminuria and estimated glomerular filtration longitudinal change in middle-aged adults from Spain: The Aragon workers health study 2023 Access copy available to the general public Unrestricted The nephrotoxicity of low-chronic metal exposures is unclear, especially considering several metals simultaneously. We assessed the individual and joint association of metals with longitudinal change in renal endpoints in Aragon Workers Health Study participants with available measures of essential (cobalt [Co], copper [Cu], molybdenum [Mo] and zinc [Zn]) and non-essential (As, barium [Ba], Cd, chromium [Cr], antimony [Sb], titanium [Ti], uranium [U], vanadium [V] and tungsten [W]) urine metals and albumin-to-creatinine ratio (ACR) (N = 707) and estimated glomerular filtration rate (eGFR) (N = 1493) change. Median levels were 0.24, 7.0, 18.6, 295, 3.1, 1.9, 0.28, 1.16, 9.7, 0.66, 0.22 μg/g for Co, Cu, Mo, Zn, As, Ba, Cd, Cr, Sb, Ti, V and W, respectively, and 52.5 and 27.2 ng/g for Sb and U, respectively. In single metal analysis, higher As, Cr and W concentrations were associated with increasing ACR annual change. Higher Zn, As and Cr concentrations were associated with decreasing eGFR annual change. The shape of the longitudinal dose-responses, however, was compatible with a nephrotoxic role for all metals, both in ACR and eGFR models. In joint metal analysis, both higher mixtures of Cu–Zn–As–Ba–Ti–U–V–W and Co–Cd–Cr–Sb–V–W showed associations with increasing ACR and decreasing eGFR annual change. As and Cr were main drivers of the ACR change joint metal association. For the eGFR change joint metal association, while Zn and Cr were main drivers, other metals also contributed substantially. We identified potential interactions for As, Zn and W by other metals with ACR change, but not with eGFR change. Our findings support that Zn, As, Cr and W and suggestively other metals, are nephrotoxic at relatively low exposure levels. Metal exposure reduction and mitigation interventions may improve prevention and decrease the burden of renal disease in the population. info:eu-repo/grantAgreement/ES/AEI/PID2019-108973RB-C21 info:eu-repo/grantAgreement/ES/ISCIII/PI15-00071 info:eu-repo/semantics/openAccess by-nc-nd http://creativecommons.org/licenses/by-nc-nd/3.0/es/ 7.6 2023 ENVIRONMENTAL SCIENCES 37 / 358 = 0.103 2023 Q1 T1 2.132 2023 Health, Toxicology and Mutagenesis 2023 Q1 Toxicology 2023 Q1 Pollution 2023 Q1 Medicine (miscellaneous) 2023 Q1 16.0 2023 info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion Domingo-Relloso, A. García-Barrera, T. Gómez-Ariza, J. L. León-Latre, Montserrat Universidad de Zaragoza Casasnovas, J. A. Universidad de Zaragoza (orcid)0000-0002-9887-2629 Moreno-Franco, B. Universidad de Zaragoza (orcid)0000-0003-0604-5042 Laclaustra, M. Universidad de Zaragoza (orcid)0000-0003-3963-0846 Guallar, E. Navas-Acien, A. Pastor-Barriuso, R. Redon, J. Tellez-Plaza, M. 1007 610 Universidad de Zaragoza Dpto. Medicina, Psiqu. y Derm. Area Medicina 1011 615 Universidad de Zaragoza Dpto. Microb.Ped.Radio.Sal.Pú. Área Medic.Prevent.Salud Públ. 318 (2023), 120851 [11 pp.] Environ. pollut. Environmental Pollution 0269-7491 654700 http://zaguan.unizar.es/record/129353/files/texto_completo.pdf Postprint 1428905 http://zaguan.unizar.es/record/129353/files/texto_completo.jpg?subformat=icon icon Postprint oai:zaguan.unizar.es:129353 articulos driver 2024-11-22-12:00:06 ARTICLE