000129505 001__ 129505 000129505 005__ 20250210083428.0 000129505 0247_ $$2doi$$a10.1186/s12906-023-04240-0 000129505 0248_ $$2sideral$$a135749 000129505 037__ $$aART-2023-135749 000129505 041__ $$aeng 000129505 100__ $$aGasión, Virginia 000129505 245__ $$aEffectiveness of an amygdala and insula retraining program combined with mindfulness training to improve the quality of life in patients with long COVID: a randomized controlled trial protocol 000129505 260__ $$c2023 000129505 5060_ $$aAccess copy available to the general public$$fUnrestricted 000129505 5203_ $$aBackground: There has been growing clinical awareness in recent years of the long-term physical and psychological consequences of the SARS-CoV-2 virus, known as Long COVID. The prevalence of Long COVID is approximately 10% of those infected by the virus. Long COVID is associated with physical and neuropsychological symptoms, including those related to mental health, psychological wellbeing, and cognition. However, research on psychological interventions is still in its early stages, in which means that available results are still limited. The main objective of this study is to evaluate the effects of a program based on amygdala and insula retraining (AIR) combined with mindfulness training (AIR + Mindfulness) on the improvement of quality of life, psychological well-being, and cognition in patients with Long COVID. Methods: This study protocol presents a single-blind randomized controlled trial (RCT) that encompasses baseline, post-treatment, and six-month follow-up assessment time points. A total of 100 patients diagnosed with Long COVID by the Spanish National Health Service will be randomly assigned to either AIR + Mindfulness (n = 50) or relaxation intervention (n = 50), the latter as a control group. The primary outcome will be quality of life assessed using the Short Form-36 Health Survey (SF-36). Additional outcomes such as fatigue, pain, anxiety, memory, and sleep quality will also be evaluated. Mixed effects regression models will be used to estimate the effectiveness of the program, and effect size calculations will be made. Discussion: Long COVID syndrome is a clinical condition characterized by the persistence of symptoms for at least 12 weeks after the onset of COVID-19 that significantly affects people’s quality of life. This will be the first RCT conducted in Spain to apply a psychotherapy program for the management of symptoms derived from Long COVID. Positive results from this RCT may have a significant impact on the clinical context by confirming the beneficial effect of the intervention program being evaluated on improving the symptoms of Long COVID syndrome and aiding the development of better action strategies for these patients. Trial registration: Clinical Trials.gov NCT05956405. 000129505 536__ $$9info:eu-repo/grantAgreement/ES/DGA/B17-23R$$9info:eu-repo/grantAgreement/ES/ISCIII/CIBERESP/CB22-02-00052$$9info:eu-repo/grantAgreement/ES/ISCIII/CP21-00080 000129505 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/ 000129505 590__ $$a3.3$$b2023 000129505 592__ $$a0.673$$b2023 000129505 591__ $$aINTEGRATIVE & COMPLEMENTARY MEDICINE$$b9 / 43 = 0.209$$c2023$$dQ1$$eT1 000129505 593__ $$aComplementary and Alternative Medicine$$c2023$$dQ1 000129505 594__ $$a6.1$$b2023 000129505 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion 000129505 700__ $$0(orcid)0000-0002-2116-9257$$aBarceló-Soler, Alberto$$uUniversidad de Zaragoza 000129505 700__ $$0(orcid)0000-0003-0786-535X$$aBeltrán-Ruiz, María$$uUniversidad de Zaragoza 000129505 700__ $$aHijar-Aguinaga, Rinchen$$uUniversidad de Zaragoza 000129505 700__ $$0(orcid)0009-0009-0106-7673$$aCamarero-Grados, Loreto 000129505 700__ $$0(orcid)0000-0002-1690-4130$$aLópez-del-Hoyo, Yolanda$$uUniversidad de Zaragoza 000129505 700__ $$0(orcid)0000-0002-3797-4218$$aGarcía-Campayo, Javier$$uUniversidad de Zaragoza 000129505 700__ $$aMontero-Marin, Jesus 000129505 7102_ $$14009$$2740$$aUniversidad de Zaragoza$$bDpto. Psicología y Sociología$$cÁrea Psicología Social 000129505 7102_ $$14009$$2730$$aUniversidad de Zaragoza$$bDpto. Psicología y Sociología$$cÁrea Psicología Básica 000129505 7102_ $$11007$$2745$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Psiquiatría 000129505 7102_ $$14009$$2735$$aUniversidad de Zaragoza$$bDpto. Psicología y Sociología$$cÁrea Psicolog.Evolut.Educac 000129505 773__ $$g23, 1 (2023), 403 [12 pp.]$$pBMC complement. med. ther.$$tBMC complementary medicine and therapies$$x2662-7671 000129505 8564_ $$s1002658$$uhttps://zaguan.unizar.es/record/129505/files/texto_completo.pdf$$yVersión publicada 000129505 8564_ $$s2217793$$uhttps://zaguan.unizar.es/record/129505/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada 000129505 909CO $$ooai:zaguan.unizar.es:129505$$particulos$$pdriver 000129505 951__ $$a2025-02-10-08:31:24 000129505 980__ $$aARTICLE