000129509 001__ 129509
000129509 005__ 20241125101147.0
000129509 0247_ $$2doi$$a10.3390/biomedicines11112986
000129509 0248_ $$2sideral$$a135808
000129509 037__ $$aART-2023-135808
000129509 041__ $$aeng
000129509 100__ $$0(orcid)0000-0002-6591-0801$$aOtin, Sofia$$uUniversidad de Zaragoza
000129509 245__ $$aDetecting Structural Changes in the Choroidal Layer of the Eye in Neurodegenerative Disease Patients through Optical Coherence Tomography Image Processing
000129509 260__ $$c2023
000129509 5060_ $$aAccess copy available to the general public$$fUnrestricted
000129509 5203_ $$aPurpose: To evaluate alterations of the choroid in patients with a neurodegenerative disease versus healthy controls, a custom algorithm based on superpixel segmentation was used. Design: A cross-sectional study was conducted on data obtained in a previous cohort study. Subjects: Swept-source optical coherence tomography (OCT) B-scan images obtained using a Triton (Topcon, Japan) device were compiled according to current OSCAR IB and APOSTEL OCT image quality criteria. Images were included from three cohorts: multiple sclerosis (MS) patients, Parkinson disease (PD) patients, and healthy subjects. Only patients with early-stage MS and PD were included. Methods: In total, 104 OCT B-scan images were processed using a custom superpixel segmentation (SpS) algorithm to detect boundary limits in the choroidal layer and the optical properties of the image. The algorithm groups pixels with similar structural properties to generate clusters with similar meaningful properties. Main outcomes: SpS selects and groups the superpixels in a segmented choroidal area, computing the choroidal optical image density (COID), measured as the standard mean gray level, and the total choroidal area (CA), measured as px2. Results: The CA and choroidal density (CD) were significantly reduced in the two neurodegenerative disease groups (higher in PD than in MS) versus the healthy subjects (p < 0.001); choroidal area was also significantly reduced in the MS group versus the healthy subjects. The COID increased significantly in the PD patients versus the MS patients and in the MS patients versus the healthy controls (p < 0.001). Conclusions: The SpS algorithm detected choroidal tissue boundary limits and differences optical density in MS and PD patients versus healthy controls. The application of the SpS algorithm to OCT images potentially acts as a non-invasive biomarker for the early diagnosis of MS and PD.
000129509 536__ $$9info:eu-repo/grantAgreement/ES/ISCIII/PI17-01726$$9info:eu-repo/grantAgreement/ES/ISCIII/PI20-00437
000129509 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000129509 590__ $$a3.9$$b2023
000129509 592__ $$a0.962$$b2023
000129509 591__ $$aPHARMACOLOGY & PHARMACY$$b85 / 354 = 0.24$$c2023$$dQ1$$eT1
000129509 593__ $$aMedicine (miscellaneous)$$c2023$$dQ1
000129509 591__ $$aBIOCHEMISTRY & MOLECULAR BIOLOGY$$b106 / 313 = 0.339$$c2023$$dQ2$$eT2
000129509 593__ $$aBiochemistry, Genetics and Molecular Biology (miscellaneous)$$c2023$$dQ1
000129509 591__ $$aMEDICINE, RESEARCH & EXPERIMENTAL$$b65 / 189 = 0.344$$c2023$$dQ2$$eT2
000129509 594__ $$a5.2$$b2023
000129509 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000129509 700__ $$0(orcid)0000-0002-9068-7728$$aÁvila, Francisco J.$$uUniversidad de Zaragoza
000129509 700__ $$aMallen, Victor
000129509 700__ $$0(orcid)0000-0001-6258-2489$$aGarcia-Martin, Elena$$uUniversidad de Zaragoza
000129509 7102_ $$11013$$2646$$aUniversidad de Zaragoza$$bDpto. Cirugía$$cÁrea Oftalmología
000129509 7102_ $$12002$$2647$$aUniversidad de Zaragoza$$bDpto. Física Aplicada$$cÁrea Óptica
000129509 773__ $$g11, 11 (2023), 2986 [13 pp.]$$tBiomedicines$$x2227-9059
000129509 8564_ $$s4547042$$uhttps://zaguan.unizar.es/record/129509/files/texto_completo.pdf$$yVersión publicada
000129509 8564_ $$s2771238$$uhttps://zaguan.unizar.es/record/129509/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000129509 909CO $$ooai:zaguan.unizar.es:129509$$particulos$$pdriver
000129509 951__ $$a2024-11-22-12:04:47
000129509 980__ $$aARTICLE