129581 20241125101202.0 doi 10.3390/s23239454 sideral 135613 ART-2023-135613 eng Sannino, Andrea Universidad de Zaragoza (orcid)0000-0001-9710-0910 A Flexible PDMS-Based Optical Biosensor for Stretch Monitoring in Cardiac Tissue Samples 2023 Access copy available to the general public Unrestricted Cardiotoxicity, characterized by adverse impacts on normal heart function due to drug exposure, is a significant concern due to the potentially serious side effects associated with various pharmaceuticals. It is essential to detect the cardiotoxicity of a drug as early as possible in the testing phase of a medical composite. Therefore, there is a pressing need for more reliable in vitro models that accurately mimic the in vivo conditions of cardiac biopsies. In a functional beating heart, cardiac muscle cells are under the effect of static and cyclic stretches. It has been demonstrated that cultured cardiac biopsies can benefit from external mechanical loads that resemble the in vivo condition, increasing the probability of cardiotoxicity detection in the early testing stages. In this work, a biosensor is designed and fabricated to allow for stretch monitoring in biopsies and tissue cultures using an innovative sensing mechanism. The detection setup is based on a biocompatible, thin, flexible membrane—where the samples are attached—which is used as an optical waveguide to detect pressure-caused shape changes and stretches. Various prototypes have been fabricated with a cost-effective process, and different measurements have been carried out to experimentally validate the proposed measurement technique. From these evaluations, stretches of up to 1.5% have been measured, but the performed simulations point towards the possibility of expanding the considered technique up to 10–30% stretches. info:eu-repo/grantAgreement/ES/DGA/GEPM T23-23 info:eu-repo/grantAgreement/ES/DGA/LMP94_21 info:eu-repo/grantAgreement/ES/DGA/T39-23R info:eu-repo/grantAgreement/EC/H2020/638284/EU/Is your heart aging well? A systems biology approach to characterize cardiac aging from the cell to the body surface/MODELAGE This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 638284-MODELAGE info:eu-repo/grantAgreement/ES/MICINN/PID2019-105674RB-I00 info:eu-repo/grantAgreement/ES/MICINN/PID2022-140556OB-I00 info:eu-repo/grantAgreement/EUR/MICINN/TED2021-130459B-I00 info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 3.4 2023 CHEMISTRY, ANALYTICAL 34 / 106 = 0.321 2023 Q2 T1 INSTRUMENTS & INSTRUMENTATION 24 / 76 = 0.316 2023 Q2 T1 ENGINEERING, ELECTRICAL & ELECTRONIC 122 / 353 = 0.346 2023 Q2 T2 0.786 2023 Instrumentation 2023 Q1 Analytical Chemistry 2023 Q1 Atomic and Molecular Physics, and Optics 2023 Q1 Information Systems 2023 Q2 Medicine (miscellaneous) 2023 Q2 Biochemistry 2023 Q2 Electrical and Electronic Engineering 2023 Q2 7.3 2023 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Velarte, Antonio Universidad de Zaragoza (orcid)0000-0003-4361-6676 Otín, Aránzazu Universidad de Zaragoza (orcid)0000-0003-1403-1505 Artigas, José Ignacio Universidad de Zaragoza (orcid)0000-0002-8007-5613 Oliván-Viguera, Aida (orcid)0000-0001-5348-924X 5008 785 Universidad de Zaragoza Dpto. Ingeniería Electrón.Com. Área Tecnología Electrónica 5008 800 Universidad de Zaragoza Dpto. Ingeniería Electrón.Com. Área Teoría Señal y Comunicac. 23, 23 (2023), 9454 [17 pp.] Sensors Sensors 1424-8220 11397744 http://zaguan.unizar.es/record/129581/files/texto_completo.pdf Versión publicada 2735607 http://zaguan.unizar.es/record/129581/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:129581 articulos driver 2024-11-22-12:11:59 ARTICLE