000129583 001__ 129583
000129583 005__ 20241125101202.0
000129583 0247_ $$2doi$$a10.3390/ijms242216143
000129583 0248_ $$2sideral$$a135856
000129583 037__ $$aART-2023-135856
000129583 041__ $$aeng
000129583 100__ $$0(orcid)0000-0003-3392-7200$$aIrún, Pilar
000129583 245__ $$aPharmacokinetics and Changes in Lipid Mediator Profiling after Consumption of Specialized Pro-Resolving Lipid-Mediator-Enriched Marine Oil in Healthy Subjects
000129583 260__ $$c2023
000129583 5060_ $$aAccess copy available to the general public$$fUnrestricted
000129583 5203_ $$aOmega-3 polyunsaturated fatty acids (PUFAs) play a vital role in human health, well-being, and the management of inflammatory diseases. Insufficient intake of omega-3 is linked to disease development. Specialized pro-resolving mediators (SPMs) are derived from omega-3 PUFAs and expedite the resolution of inflammation. They fall into categories known as resolvins, maresins, protectins, and lipoxins. The actions of SPMs in the resolution of inflammation involve restricting neutrophil infiltration, facilitating the removal of apoptotic cells and cellular debris, promoting efferocytosis and phagocytosis, counteracting the production of pro-inflammatory molecules like chemokines and cytokines, and encouraging a pro-resolving macrophage phenotype. This is an experimental pilot study in which ten healthy subjects were enrolled and received a single dose of 6 g of an oral SPM-enriched marine oil emulsion. Peripheral blood was collected at baseline, 3, 6, 9, 12, and 24 h post-administration. Temporal increases in plasma and serum SPM levels were found by using LC-MS/MS lipid profiling. Additionally, we characterized the temporal increases in omega-3 levels and established fundamental pharmacokinetics in both aforementioned matrices. These findings provide substantial evidence of the time-dependent elevation of SPMs, reinforcing the notion that oral supplementation with SPM-enriched products represents a valuable source of essential bioactive SPMs.
000129583 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000129583 590__ $$a4.9$$b2023
000129583 592__ $$a1.179$$b2023
000129583 591__ $$aBIOCHEMISTRY & MOLECULAR BIOLOGY$$b66 / 313 = 0.211$$c2023$$dQ1$$eT1
000129583 593__ $$aMedicine (miscellaneous)$$c2023$$dQ1
000129583 591__ $$aCHEMISTRY, MULTIDISCIPLINARY$$b68 / 231 = 0.294$$c2023$$dQ2$$eT1
000129583 593__ $$aPhysical and Theoretical Chemistry$$c2023$$dQ1
000129583 593__ $$aComputer Science Applications$$c2023$$dQ1
000129583 593__ $$aInorganic Chemistry$$c2023$$dQ1
000129583 593__ $$aSpectroscopy$$c2023$$dQ1
000129583 593__ $$aOrganic Chemistry$$c2023$$dQ1
000129583 593__ $$aMolecular Biology$$c2023$$dQ2
000129583 593__ $$aCatalysis$$c2023$$dQ2
000129583 594__ $$a8.1$$b2023
000129583 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000129583 700__ $$aCarrera-Lasfuentes, Patricia
000129583 700__ $$aSánchez-Luengo, Marta
000129583 700__ $$0(orcid)0000-0002-9652-0662$$aBelio, Úrsula
000129583 700__ $$aDomper-Arnal, María José$$uUniversidad de Zaragoza
000129583 700__ $$aHiguera, Gustavo A.
000129583 700__ $$aHawkins, Malena
000129583 700__ $$ade la Rosa, Xavier
000129583 700__ $$0(orcid)0000-0001-5932-2889$$aLanas, Angel$$uUniversidad de Zaragoza
000129583 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000129583 773__ $$g24, 22 [23 pp.] (2023), 16143$$pInt. j. mol. sci.$$tInternational Journal of Molecular Sciences$$x1661-6596
000129583 8564_ $$s15821422$$uhttps://zaguan.unizar.es/record/129583/files/texto_completo.pdf$$yVersión publicada
000129583 8564_ $$s2738124$$uhttps://zaguan.unizar.es/record/129583/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000129583 909CO $$ooai:zaguan.unizar.es:129583$$particulos$$pdriver
000129583 951__ $$a2024-11-22-12:12:01
000129583 980__ $$aARTICLE