129583 20241125101202.0 doi 10.3390/ijms242216143 sideral 135856 ART-2023-135856 eng Irún, Pilar (orcid)0000-0003-3392-7200 Pharmacokinetics and Changes in Lipid Mediator Profiling after Consumption of Specialized Pro-Resolving Lipid-Mediator-Enriched Marine Oil in Healthy Subjects 2023 Access copy available to the general public Unrestricted Omega-3 polyunsaturated fatty acids (PUFAs) play a vital role in human health, well-being, and the management of inflammatory diseases. Insufficient intake of omega-3 is linked to disease development. Specialized pro-resolving mediators (SPMs) are derived from omega-3 PUFAs and expedite the resolution of inflammation. They fall into categories known as resolvins, maresins, protectins, and lipoxins. The actions of SPMs in the resolution of inflammation involve restricting neutrophil infiltration, facilitating the removal of apoptotic cells and cellular debris, promoting efferocytosis and phagocytosis, counteracting the production of pro-inflammatory molecules like chemokines and cytokines, and encouraging a pro-resolving macrophage phenotype. This is an experimental pilot study in which ten healthy subjects were enrolled and received a single dose of 6 g of an oral SPM-enriched marine oil emulsion. Peripheral blood was collected at baseline, 3, 6, 9, 12, and 24 h post-administration. Temporal increases in plasma and serum SPM levels were found by using LC-MS/MS lipid profiling. Additionally, we characterized the temporal increases in omega-3 levels and established fundamental pharmacokinetics in both aforementioned matrices. These findings provide substantial evidence of the time-dependent elevation of SPMs, reinforcing the notion that oral supplementation with SPM-enriched products represents a valuable source of essential bioactive SPMs. info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 4.9 2023 BIOCHEMISTRY & MOLECULAR BIOLOGY 66 / 313 = 0.211 2023 Q1 T1 CHEMISTRY, MULTIDISCIPLINARY 68 / 231 = 0.294 2023 Q2 T1 1.179 2023 Medicine (miscellaneous) 2023 Q1 Physical and Theoretical Chemistry 2023 Q1 Computer Science Applications 2023 Q1 Inorganic Chemistry 2023 Q1 Spectroscopy 2023 Q1 Organic Chemistry 2023 Q1 Molecular Biology 2023 Q2 Catalysis 2023 Q2 8.1 2023 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Carrera-Lasfuentes, Patricia Sánchez-Luengo, Marta Belio, Úrsula (orcid)0000-0002-9652-0662 Domper-Arnal, María José Universidad de Zaragoza Higuera, Gustavo A. Hawkins, Malena de la Rosa, Xavier Lanas, Angel Universidad de Zaragoza (orcid)0000-0001-5932-2889 1007 610 Universidad de Zaragoza Dpto. Medicina, Psiqu. y Derm. Area Medicina 24, 22 [23 pp.] (2023), 16143 Int. j. mol. sci. International Journal of Molecular Sciences 1661-6596 15821422 http://zaguan.unizar.es/record/129583/files/texto_completo.pdf Versión publicada 2738124 http://zaguan.unizar.es/record/129583/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:129583 articulos driver 2024-11-22-12:12:01 ARTICLE