000129584 001__ 129584
000129584 005__ 20231221152908.0
000129584 0247_ $$2doi$$a10.31488/EJRM.136
000129584 0248_ $$2sideral$$a135743
000129584 037__ $$aART-2022-135743
000129584 041__ $$aeng
000129584 100__ $$aMatovelle-Ochoa, Priscila$$uUniversidad de Zaragoza
000129584 245__ $$aBiomarkers as prognosis of Covid-19 disease: retrospective cohort study
000129584 260__ $$c2022
000129584 5060_ $$aAccess copy available to the general public$$fUnrestricted
000129584 5203_ $$aCoronavirus infection has been the cause of millions of deaths worldwide. Some analytical parameters on admission could help predict prognosis and mortality. This study aims to describe the main Laboratory findings of hospitalized patients with COVID-19 and to identify the relationship between intensive care unit access, length of stay and in-hospital mortality. Methods: A retrospective cohort study was performed. Demographic and analytical variables of all patients diagnosed with COVID-19 hospitalized in Aragon (Spain) between March and June 2020 were analyzed. Results: We describe the characteristics of 2640 patients hospitalized with COVID-19, 85% were significantly older, with a median age of 72.3 ± 16.7 years, predominantly male (52.8%). The in-hospital mortality rate was 30%. Patients admitted to the intensive care unit had significantly higher baseline levels of hematocrit, fibrinogen, lactate dehydrogenase, leukocytes and neutrophils (p<0.001 in all). On the other hand, these patients had lower levels of eosinophils, lymphocytes and monocytes (p<0.001 in all). Only hemoglobin and D-dimer showed a significant and positive correlation with longer hospital and ICU stays (r=0.050 with p=0.031; r=0.203 with p=0.008; r=0.175 with p<0.001 and r=0.199 with p=0.001, respectively. Multivariable regression based on death showed that age, higher values of lactate dehydrogenase, neutrophils and lower values of eosinophils and female sex could explain up to 30% of the probability of death. Conclusion: Laboratory parameters can help clinicians predict the severity of COVID-19 and subsequently improve prognosis and decrease mortality rates. However, more studies are needed to better understand these changes and their relationship to prognosis.
000129584 536__ $$9info:eu-repo/grantAgreement/ES/DGA/B21-20R
000129584 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000129584 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000129584 700__ $$0(orcid)0000-0001-6565-9699$$aOliván-Blázquez, Bárbara$$uUniversidad de Zaragoza
000129584 700__ $$0(orcid)0000-0002-5494-6550$$aMagallón-Botaya, Rosa$$uUniversidad de Zaragoza
000129584 700__ $$aLamiquiz-Moneo, Itziar
000129584 700__ $$0(orcid)0000-0002-6409-9041$$aMéndez López de la Manzanara, Fátima
000129584 700__ $$0(orcid)0000-0001-8820-9105$$aBartolomé-Moreno, Cruz$$uUniversidad de Zaragoza
000129584 7102_ $$14009$$2740$$aUniversidad de Zaragoza$$bDpto. Psicología y Sociología$$cÁrea Psicología Social
000129584 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000129584 773__ $$g4, 3 (2022), 344-341$$pEur. j. respir. med.$$tEuropean journal of respiratory medicine$$x2633-7452
000129584 8564_ $$s386124$$uhttps://zaguan.unizar.es/record/129584/files/texto_completo.pdf$$yVersión publicada
000129584 8564_ $$s2593997$$uhttps://zaguan.unizar.es/record/129584/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000129584 909CO $$ooai:zaguan.unizar.es:129584$$particulos$$pdriver
000129584 951__ $$a2023-12-21-13:10:12
000129584 980__ $$aARTICLE