000129609 001__ 129609
000129609 005__ 20240104102231.0
000129609 0247_ $$2doi$$a10.1002/cbin.10865
000129609 0248_ $$2sideral$$a103522
000129609 037__ $$aART-2017-103522
000129609 041__ $$aeng
000129609 100__ $$aGasco, S.
000129609 245__ $$aComparative study of hematopoietic stem and progenitor cells between sexes in mice under physiological conditions along time
000129609 260__ $$c2017
000129609 5060_ $$aAccess copy available to the general public$$fUnrestricted
000129609 5203_ $$aHematopoietic stem and progenitor cells (HSPCs) are attractive targets in regenerative medicine, although the differences in their homeostatic maintenance between sexes along time are still under debate. We accurately monitored hematopoietic stem cells (HSCs), common lymphoid progenitors (CLPs), and common myeloid progenitors (CMPs) frequencies by flow cytometry, by performing serial peripheral blood extractions from male and female B6SJL wild-type mice and found no significant differences. Only modest differences were found in the gene expression profile of Slamf1 and Gata2. Our findings suggest that both sexes could be used indistinctly to perform descriptive studies in the murine hematopoietic system, especially for flow cytometry studies in peripheral blood. This would allow diminishing the number of animals needed for the experimental procedures. In addition, the use of serial extractions in the same animals drastically decreases the number of animals needed.
000129609 536__ $$9info:eu-repo/grantAgreement/ES/FIS/PI14-00947
000129609 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000129609 590__ $$a1.936$$b2017
000129609 591__ $$aCELL BIOLOGY$$b153 / 190 = 0.805$$c2017$$dQ4$$eT3
000129609 592__ $$a0.712$$b2017
000129609 593__ $$aMedicine (miscellaneous)$$c2017$$dQ2
000129609 593__ $$aCell Biology$$c2017$$dQ3
000129609 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000129609 700__ $$0(orcid)0000-0002-2898-4561$$aRando, A.
000129609 700__ $$0(orcid)0000-0001-5740-0185$$aZaragoza, P.$$uUniversidad de Zaragoza
000129609 700__ $$aGarcía-Redondo, A.
000129609 700__ $$0(orcid)0000-0001-5193-7782$$aCalvo, A.C.$$uUniversidad de Zaragoza
000129609 700__ $$0(orcid)0000-0001-5687-6704$$aOsta, R.$$uUniversidad de Zaragoza
000129609 7102_ $$11001$$2420$$aUniversidad de Zaragoza$$bDpto. Anatom.,Embri.Genét.Ani.$$cÁrea Genética
000129609 773__ $$g41, 12 (2017), 1399-1405$$pCell biol. int.$$tCELL BIOLOGY INTERNATIONAL$$x1065-6995
000129609 8564_ $$s251882$$uhttps://zaguan.unizar.es/record/129609/files/texto_completo.pdf$$yPostprint
000129609 8564_ $$s2386215$$uhttps://zaguan.unizar.es/record/129609/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
000129609 909CO $$ooai:zaguan.unizar.es:129609$$particulos$$pdriver
000129609 951__ $$a2024-01-04-09:04:52
000129609 980__ $$aARTICLE